2225938-17-8

MS1943 (150 mg/kg body weight; i.p.; once daily for 36 days) suppresses tumor growth^[1].
MS1943 induces apoptosis in the MDA-MB-468 xenograft model^[1].
A single i.p. injection of MS1943 at 50 mg/kg body weight achieved a peak plasma concentration (Cmax) of 2.9 μM and resulted in plasma concentrations above its cellular IC₅₀ value for ~2h. A single 150 mg/kg body weight p.o. dose achieved Cmax of 1.1 μM, but plasma concentrations were below the cellular IC₅₀ value^[1].