Soluble in DMSO:100.0(Max Conc. mg/mL);139.1(Max Conc. mM)
form
A solid
pka
12.56±0.46(Predicted)
color
Light yellow to yellow
Usage And Synthesis
Uses
MS1943 is used in the preparation of heterocyclic compounds as EZH2 ligands and their compositions and methods for treating EZH2-mediated cancer. MS1943 itself significantly reduces EZH2 protein levels in numerous triple-negative breast cancer
Biological Activity
MS1943 is a potent and selective degrader of EZH2 (enhancer of zeste homolog 2) th at effectively reduces EZH2 levels in cells. MS1943 potently inhibits growth of multiple TNBC cells and in mice xenograft model.