What is the use and Side Effects of Ribociclib?

Ribociclib is a cyclin-dependent kinase 4/6 (CDK 4/6) inhibitor, which means it targets two specific kinases, or proteins, that help tumor cells reproduce. Those kinases are CDK 4 and CDK 6. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps slow or stop the spread of cancer cells.

Use

Ribociclib (Kisqali) is a targeted therapy approved by the Food and Drug Administration to treat stage II, stage III, and advanced or metastatic hormone receptor-positive, HER2-negative breast cancer.

How ribociclib is given

Ribociclib comes as a tablet to take by mouth. It is usually taken with or without food once daily in the morning for the first 21 days of a 28-day cycle. Take ribociclib at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take ribociclib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the tablets whole; do not split, chew, or crush them. Do not take tablets that are broken or crushed.

If you vomit after taking ribociclib, do not take another dose. Continue your regular dosing schedule.

Side Effects

The most common side effects include infections, low levels of white blood cells, headache, cough, nausea (feeling sick), vomiting, diarrhea, constipation, tiredness, hair loss and rash.

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