What is the function and Uses of Salicylamide?

Salicylamide is an over-the-counter drug popularly used as an analgesic and antipyretic.

Uses

Salicylamide's medicinal uses are similar to those of aspirin.Salicylamide is used in combination with both aspirin and caffeine in the over-the-counter pain remedy PainAid. It was also an ingredient in the over-the-counter pain remedy BC Powder but was removed from the formulation in 2009, and Excedrin used the ingredient from 1960 to 1980 in conjunction with aspirin, acetaminophen, and caffeine.

Function

Evidence for mutual inhibition of in vivo glucuronidation for salicylic acid and salicylamide (Levy & Procknal, 1968) and for salicylic acid and zomepirac (Desiraju et al., 1984) has been provided. Salicylamide has also been reported to inhibit paracetamol glucuronidation (Levy & Yamada, 1971). Paracetamol conjugation recently was found to be inhibited by novobiocin in pig liver microsomes (Villar et al., 1998). Both naloxone and morphine were shown to serve as competitive inhibitors of the 3-glucuronidation of the other substrate in human liver microsomes. The Ki values revealed a higher affinity of naloxone for the enzyme-binding site. 1

Metabolism

Salicylamide gets metabolized in the liver by glucuronidation and produces its metabolites, salicylamide sulfate, salicylamide glucuronide, and gentisamide glucuronide, eliminating it rapidly. Song et al. studied the PK profile of salicylamide in pyrogen-induced fever.

1 Konstantin Grancharov, Zlatina Naydenova, Svetla Lozeva, Evgeny Golovinsky, Natural and synthetic inhibitors of UDP-glucuronosyltransferase,Pharmacology & Therapeutics,Volume 89, Issue 2,2001,Pages 171-186.

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