What is orotic acid used for?

Orotic acid, once known as vitamin B13, is a compound produced by the body and is primarily used in dietary supplements as a carrier for minerals like magnesium, calcium, and lithium to enhance their bioavailability. For instance, magnesium orotate is often promoted for improving heart health and athletic performance, although strong scientific evidence for the latter is lacking. Beyond supplements, orotic acid is utilized in cosmetic creams for its anti-aging and moisturizing properties, and it has medical applications in treating certain liver and heart conditions. As a precursor in the synthesis of nucleic acids, it is also significant in genetic and metabolic research. However, it is no longer classified as a vitamin, and high doses have raised safety concerns in some studies, with potential side effects like diarrhea from excessive supplement intake.

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