What is 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine used for?

1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE) is an important component of biological membranes and is a phospholipid member of the glycerophosphatidylethanolamine family. 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE) is used in the preparation of micelles for drug carriers, such as dextran- pla - dppe copolymer and Pluronic (F68) -DPPE copolymer micelles. In addition, studies of DPPE-cholesterol interactions have shown that DPPE is miscible with CHOL in the cholesterol molar fraction (xCHOL = 0.3 ~ 0.5) range. Cholesterol induced polycondensation of DPPE monolayers. At xCHOL = 0.4, the condensation of DPPE/CHOL monolayers was most significant when Ca2+ ions were present in the subphase.

References

[1] HUAN WANG . Preparation of dextran–poly(lactide)–1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine copolymer and its micellar characteristics[J]. Carbohydrate Polymers, 2011. DOI:10.1016/j.carbpol.2010.10.028.

[2] BEATA KORCHOWIEC . A Langmuir film approach to elucidating interactions in lipid membranes: 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine/cholesterol/metal cation systems[J]. Chemistry and Physics of Lipids, 2006. DOI:10.1016/j.chemphyslip.2006.08.005.

[3] TIEWEI WANG; Ai J Z; Yan Wu. Synthesis and characterization of amphiphilic pluronic (F68)-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine copolymers and their micelles as a drug carrier[J]. Journal of Applied Polymer Science, 2010. DOI:10.1002/app.31231.

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