What drugs contain benzothiophene?

The benzothiophene skeleton is an important structure in medicinal chemistry, present in key drugs across a variety of therapeutic classes, most notably the anti-estrogenic drug raloxifene. Raloxifene is a selective estrogen receptor modulator (SERM) primarily used for the prevention and treatment of osteoporosis in postmenopausal women. Besides raloxifene, the benzothiophene moiety is also a component of the anti-asthmatic drug zisulphone (a leukotriene synthesis inhibitor) and the antifungal drug sertaconazole, demonstrating the structural diversity of this sulfur-containing heterocyclic compound in designing compounds with broad biological activities.

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