What are the side effects of PeraMpanel?

Perampanel is used to treat certain types of seizures (including focal and generalized tonic-clonic seizures). Perampanel belongs to a class of drugs known as anticonvulsants.

Side effects of PeraMpanel

More common

Aggression or anger; anxiety; clumsiness or unsteadiness; deep or fast breathing with dizziness; dry mouth; irregular heartbeat; irritability; numbness of the feet, hands, and around the mouth; restlessness; shakiness; sleepiness or unusual drowsiness; trouble sleeping; unsteadiness, trembling, or other problems with muscle control or coordination; unsteady walk; unusual tiredness or weakness.

Less common

Abnormal or decreased touch sensation; burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings; Incidence not known; Changes in behavior; depression; thoughts of killing oneself.

The Safety of PeraMpanel in children with epilepsy

In the previous 311 clinical studies, the common adverse drug reactions of perampanel were drowsiness (26%), nasopharyngitis (19%), dizziness (13%), irritability (13%) and fever (13%), No patients died from perampanel.

Because perampanel is metabolized by the liver, special caution should be exercised when using perampanel in patients with hepatic impairment. Previous studies have shown that perampanel has low hepatotoxicity and does not significantly increase the risk of liver injury.

In conclusion, experts recommend that adverse drug reactions should be prevented by slowly increasing the dose; adverse drug reactions should be reduced or eliminated by reducing the dose and slowing the speed of administration. For children with epilepsy with mild to moderate liver damage, it is recommended to individualize the drug according to the clinical response and tolerance, slow down the speed of administration, maintain a small dose, and monitor liver function during the medication; it is not recommended for children with severe liver damage and epilepsy.

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