What are the benefits of supplementing with betaine?

Betaine exhibits neuroprotective and hepatoprotective effects. Multiple studies indicate that betaine prevents alcohol-induced hepatic steatosis, apoptosis, and the accumulation of damaged proteins. Furthermore, it significantly prevents or mitigates progressive liver damage by maintaining intestinal integrity and lipid metabolism. Its protective action is primarily associated with regulating methionine metabolism through the removal of homocysteine and maintaining the cellular SAM:SAH ratio. Simultaneously, betaine prevents metabolic fatty liver disease and its progression. Its neuroprotective effects manifest in preserving myocardial function and preventing pancreatic steatosis. It also mitigates oxidative stress, endoplasmic reticulum stress, inflammation, and carcinogenesis. Most importantly, betaine is available as a prescription medication for treating homocystinuria. It is relatively safe, with reports of no serious side effects. Results from a randomised placebo-controlled crossover study indicate that betaine supplementation increases betaine concentration and reduces homocysteine levels, without affecting amino acid profiles or choline concentrations in healthy, active males.

You may like