What are the benefits of HBTU in peptide synthesis?

HBTU has the characteristics of high coupling efficiency, mild reaction conditions, low side reactions, and easy to use in combination with other coupling agents to achieve synergistic effects. HBTU coupling reagents are particularly suitable for the synthesis of long peptides. It can shorten the reaction time and improve the yield of peptide bond formation, thereby achieving high reactivity and coupling efficiency. Additionally, HBTU reagents effectively inhibit racemisation, forming stable intermediates and reducing the occurrence of side reactions. HBTU can also be used under mild conditions, avoiding damage to sensitive amino acids or peptide fragments. When used in combination with HOBt, HBTU further enhances coupling reaction efficiency.

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