Understanding the Side Effects and Dosage of MK 677

General Description

MK 677, also known as Ibutamoren, is a growth hormone secretagogue that can lead to water retention and increased hunger as common side effects. The recommended dosage is 25mg per day, which provides benefits without the risk of water retention and bloating. Splitting the dose throughout the day can help maintain consistent levels in the body. Other reported side effects include numbness in hands and feet, but it's not related to nerve damage, and anxiety, although inconclusive. Overall, side effects are minimal and manageable, with potential benefits for mental health and physical performance. It's important to consult with a healthcare professional before starting any new supplement regimen.

Figure 1. MK-677

Side Effects

Water Retention

MK 677, also known as Ibutamoren, is a growth hormone secretagogue that can lead to water retention as a common side effect. When the body experiences elevated levels of human growth hormone (HGH), it tends to retain water. However, a significant portion of this water is stored within the muscles, similar to the effects of creatine supplementation. Consequently, athletes may experience increased strength due to the muscle water retention caused by HGH. Nonetheless, some individuals may notice water being stored under the skin, resulting in a bloated appearance. It is worth noting that at a daily dosage of 25mg, water retention and bloating are typically not observed. To mitigate bloating, one may consider using a diuretic like dandelion root extract. ¹

Hunger

MK 677 also has been found to produce a common side effect of increased hunger. This may be beneficial to individuals on a winter bulk cycle, but it can be frustrating for those who are trying to take advantage of MK 677's anti-catabolic effects. However, it's worth noting that this side effect is temporary and usually subsides on its own after approximately two weeks. To deal with this side effect, it's recommended to start the cycle two weeks before starting a diet plan to allow the hunger to settle down first. ¹

Others

MK 677 has been reported to have other side effects apart from water retention and hunger. One of the commonly reported side effects is experiencing numbness or "pins and needles" sensations in the hands and feet. This side effect is not dangerous and is considered a common reaction to growth hormone. Although doctors do not know why this happens, they agree that it's not related to nerve damage. Another potential side effect of MK 677 is anxiety. While there are no studies that list anxiety as a side effect, reports of it on the internet are scarce and inconclusive. Most experts, including the author of this article, believe that pharmacologically, MK 677 should not cause anxiety. In fact, many users report that their anxiety levels improve while taking MK 677, possibly due to the improvement in sleep quality and appetite. Overall, side effects associated with MK 677 appear to be minimal and manageable, with some potential benefits for mental health and physical performance. However, it's always important to consult with a healthcare professional before starting any new supplement regimen. ¹

Dosage

MK 677, also known as Ibutamoren, is commonly recommended at doses ranging from 10mg to 100mg per day. However, a study comparing HGH levels at different doses reveals that there is a significant diminishing return with higher doses. Beyond 25mg per day, the levels of HGH and IGF-1 in the bloodstream decrease. Therefore, the optimal dosage of MK 677 is 25mg per day, providing all the benefits without the risk of water retention and bloating. It is essential to note that MK 677 has a half-life of around 24 hours, allowing for flexibility in dosing frequency. Splitting the dose between morning and night, or even into three doses throughout the day, can help maintain consistent levels in the body. When choosing a form of MK 677, liquids offer advantages over capsules, pills, or powders. Liquids provide greater dosing flexibility and accuracy, making it easier to split doses and ensuring precise measurement, which can be challenging with powders or capsules. Therefore, opting for liquid form is recommended for better control and effectiveness of MK 677 supplementation. ²

Reference

1. Bach MA, Rockwood K, Zetterberg C, et al. The effects of MK-0677, an oral growth hormone secretagogue, in patients with hip fracture. J Am Geriatr Soc. 2004;52(4):516-523.

2. Chris J. Beginners Guide to MK 677 (lbutamoren): Dosage, Side Effects, Reviews. Sarms. 2020.

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