Preparations and Uses of Famotidine

Famotidine is a histamine-2 blocker that works by decreasing the amount of acid the stomach produces.

Uses

Famotidine is used to treat and prevent ulcers in the stomach and intestines. It also treats conditions in which the stomach produces too much acid, such as Zollinger-Ellison syndrome.

Famotidine also treats gastroesophageal reflux disease (GERD) and other conditions in which acid backs up from the stomach into the esophagus, causing heartburn.

Side effects

The most common side effects associated with famotidine use include headache, dizziness, and constipation or diarrhea.

Famotidine may contribute to QT prolongation,particularly when used with other QT-elongating drugs, or in people with poor kidney function.

Mechanism of action

Activation of H2 receptors located on parietal cells stimulates proton pumps to secrete acid into the stomach lumen. Famotidine, an H2 antagonist, blocks the action of histamine on the parietal cells, ultimately reducing acid secretion into the stomach.

Preparations

It is taken by mouth, as a tablet or suspension, or by injection into a vein.

Certain preparations of famotidine are available over the counter (OTC) in various countries. In the United States and Canada, 10 mg and 20 mg tablets, sometimes in combination with an antacid,are available OTC. Larger doses still require a medical prescription.

Formulations of famotidine in combination with ibuprofen were marketed by Horizon Pharma under the trade name Duexis.

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