N,N-Dimethyltrimethylsilylamine:Uses,Preparation and Toxicity

N,N-Dimethyltrimethylsilylamine is a colorless odorless liquid, it is a silicone reagents.

Stability

N,N-Dimethyltrimethylsilylamine is stable under normal conditions. Moisture sensitive.

Uses

N,N-Dimethyltrimethylsilylamine can be used as a reactant to prepare:

Trifluoromethylacetophenone-N,N-dimethyltrimethylsilylamine adduct, which is used as an efficient reagent for nucleophilic trifluoromethylation of carbonyl and the imine group;

(Dimethylamino)sulfur trifluoride (Me-DAST), which is employed as a deoxofluorinating agent for the conversion of aliphatic alcohols into their corresponding fluorides;

Nucleoside phosphoramidites by reacting with alkyloxy (or aryloxy)-triazolylphosphine and deoxynucleoside;

It can also be used as a silylating agent in chemical synthesis.

Preparation

A process for producing N,N-Dimethyltrimethylsilylamine, which comprises: Trimethylchlorosilane and a solvent are added to a flask, and dimethylamine gas is introduced to obtain a crude product of N,N-dimethyltrimethylsilylamine; the crude product is distilled at atmospheric pressure and then rectified to obtain N,N-Dimethyltrimethylsilylamine.

Hazard

N,N-Dimethyltrimethylsilylamine is a highly flammable liquid and vapor, it can causes severe skin burns and eye damage. May cause respiratory irritation.

Toxicity

Inhalation of high vapor concentrations of N,N-Dimethyltrimethylsilylamine may cause symptoms like headache, dizziness, tiredness, nausea and vomiting.

Storage

Keep in a dry, cool and well-ventilated place. Keep away from heat, sparks and flame. Flammables area. Keep away from heat/sparks/open flames/hot surfaces. No smoking. Keep containers tightly closed in a dry, cool and well-ventilated place.

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