Dilauryl thiodipropionate: properties, applications in cosmetics and safety

General Description

Dilauryl thiodipropionate (DLTDP) is a white crystal solid commonly used in cosmetics. It acts as an antioxidant, stabilizer, lubricant, and emollient. DLTDP helps prevent oxidation, extends shelf life, and maintains product stability. It enhances the texture and feel of formulations, providing moisturization and a smooth sensation on the skin. DLTDP forms a protective barrier, retaining moisture and preventing water loss. It is safe for use in cosmetics, showing no significant toxicity, irritation, sensitization, or reproductive toxicity risks. Overall, dilauryl thiodipropionate offers beneficial properties in cosmetic products, contributing to their efficacy and quality.

Figure 1. Dilauryl thiodipropionate

Properties

Dilauryl thiodipropionate is a white crystal solid with a molecular formula of C30H58O4S and a molecular weight of 514.8441. It is a dialkyl ester that is derived from thiodipropionic acid and lauryl alcohol. It is commonly used in various cosmetic and personal care products due to its beneficial properties. One of the key properties of DLTDP is its antioxidant activity. It functions as a highly effective free radical scavenger, helping to inhibit the oxidation of cosmetic formulations and extend their shelf life. DLTDP also possesses emollient properties, which make it an excellent choice for skincare and haircare products. It can enhance the texture and feel of formulations, providing a smooth and moisturized sensation upon application. Additionally, DLTDP can contribute to the formation of protective barriers on the skin, helping to retain moisture and prevent transepidermal water loss. Overall, dilauryl thiodipropionate offers antioxidant, emollient, and thermal stability properties, making it a valuable ingredient in cosmetic and personal care products. Its ability to scavenge free radicals, provide moisturization, and withstand heat contributes to its efficacy and benefits in various formulations. ¹

Applications in cosmetics

Dilauryl thiodipropionate is a chemical compound commonly used in the cosmetics industry due to its advantageous properties. DLTDP is an odorless and colorless substance that acts as an antioxidant and stabilizer in various cosmetic products. One of the primary applications of DLTDP in cosmetics is as an antioxidant. It helps prevent the oxidation of oils and fats present in formulations, thereby extending the shelf life of products. By inhibiting the formation of free radicals, DLTDP protects cosmetics from deterioration caused by exposure to air, light, and heat. This property makes it particularly suitable for use in lipsticks, foundations, moisturizers, and other emulsion-based products. DLTDP also functions as a stabilizer in cosmetic formulations, especially those containing oils. It prevents the degradation of active ingredients, preserves the consistency and texture of products, and enhances their overall stability. This makes it a valuable ingredient in creams, lotions, and sunscreens. Moreover, DLTDP can act as a lubricant and emollient, providing a smooth and soft feel when applied to the skin. In conclusion, Dilauryl thiodipropionate finds wide application in cosmetics as an antioxidant, stabilizer, lubricant, and emollient. ²

Safety

Dilauryl thiodipropionate is one of several dialkyl esters of thiodipropionic acid used in cosmetics. Research indicates that DLTDP is metabolized into TDPA upon ingestion and excreted in the urine. Extensive testing has been conducted to evaluate the safety profile of DLTDP. Acute oral and parenteral studies, as well as subchronic and chronic repeated dose oral studies, have not revealed any significant toxicity associated with DLTDP. Furthermore, DLTDP have exhibited no irritation potential on animal skin or eyes, and they have not been identified as sensitizers. Additionally, DLTDP has been found to be non-teratogenic and does not pose reproductive toxicity risks. Genotoxicity studies have yielded negative results for DLTDP. Clinical testing has demonstrated some evidence of irritation, but no sensitization or photosensitization effects were observed. Based on the available data, the Cosmetic Ingredient Review Expert Panel has concluded that DLTDP can be considered safe for use in cosmetic products, particularly those formulated to be nonirritating. In summary, dilauryl thiodipropionate has been extensively studied and is considered safe for use in cosmetics. It does not exhibit significant toxicity, irritation, sensitization, or reproductive toxicity risks. ³

Reference

1. PubChem. COMPOUND SUMMARY: Dilauryl thiodipropionate. National Library of Medicine, 2005 CID:31250.

2. Diamante C, Fiume MZ, Bergfeld WF, et al. Final safety assessment of thiodipropionic acid and its dialkyl esters as used in cosmetics. Int J Toxicol. 2010;29(4 Suppl):137S-50S.

3. Elder RL. Final report on the safety assessment of dilauryl thiodipropionate. J Am Coll Toxicol, 1992, 11:25-41.

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