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1-Bromopropane:uses,synthesis,exposure and toxicity

Nov 6，2024

1-Bromopropane (1-BP) is a solvent that is used in degreasing, dry cleaning, spray adhesives, and aerosol solvents. Occupational exposure to 1-BP has been linked to neurological illnesses.

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Uses

1-Bromopropane is used as a solvent for fats, waxes, or resins and in spray adhesives, in preci sion cleaning, and as a degreaser. It also is used as an intermediate in the synthesis of pharma ceuticals, insecticides, flavors, and fragrances.

Synthesis

1-Bromopropane is produced by reacting n-propyl alcohol with hydrogen bromide and then removing wa ter that is formed. 1-BP also can be produced by dehydration of propanol with bromine or hydrogen bromide in the presence of a sulfur catalyst.

Exposure

As with many other solvents, workers can be exposed to 1-Bromopropane by breathing in vapor or mists of spray. Workers might also be exposed if the chemical touches their skin because it can be absorbed [Hanley et al. 2006; Frasch et al. 2011]. Additionally, the risk of health effects to workers increases the longer they work with or near 1-BP. Impacts on health have been seen in workers after exposures for as little as two days, although symptoms are more commonly associated with longer exposure [Ichihara et al. 2012].

Toxicity

Animal studies show that 1-Bromopropane may cause cancer and reproductive disorders.Exposure to 1-BP can cause irritation (for example, of the eyes, mucous membranes, upper airways and skin) and can damage the nervous system. Neurologic effects can appear as headaches, dizziness, loss of consciousness, slurred speech, confusion, difficulty walking, muscle twitching, and/or loss of feeling in arms and legs [Ichihara et al. 2012]. These effects may continue among affected persons even after exposure to 1-BP has ended [Majersik et al. 2007].

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