阿奇霉素

Azithromycin is an azalide antibiotic, which inhibits the growth of gram negative bacteria, such as Haemophilus influenza. Azithromycin functions by interfering with 50S ribosomal subunit formation and translation, which inhibits the formation of proteins essential for bacterial survival. Studies involving capillary electrophoresis suggest that Azithromycin can be used as a chiral selector for enantiomeric separation of compounds. In addition, Azithrmycin can be used to increase chloride efflux and selectively reduces tumor necrosis factor α in human cystic fibrosis cells. Furthermore, Azithromycin reduces LPS-induced pulmonary neutrophilia in mice, via suppressing the expression of IL-1β.