LY294002 is the first synthetic molecule known to inhibit PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM in cell-free assays, respectively; more stable in solution than Wortmannin, and also blocks autophagosome formation.
Target
p110δ
p110β
p110α
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IC50 Value
0.57μM
0.97μM
0.5μM
Diseases and Conditions
Other
体外
体内
Chemical information:
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分子量
307.34
储存条件
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3 years -20 ℃ powder
2 years -80 ℃ In solvent
分子式
C19H17NO3
CAS:
154447-36-6
备注
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
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溶解度
体外
Ethanol
21mg/mL(68.32mM)
DMSO
36mg/ml(117.13 mM)
Water
<1mg/ml
体内
2% DMSO+30% polyethylene glycol+1% Tween 80
30 mg/mL
* <1 mg/ml refers to the product slightly soluble or insoluble
