PBR RABBIT MONOCLONAL ANTIBODY

产品编号

产品名称

产品包装

产品价格

AF1024

PBR Rabbit Monoclonal Antibody

50μl

618.00元

来源

用途

交叉反应性

分子量

Rabbit

WB, IP, IF, IHC, ICC, FC

H, M

18.0kDa

WB

IP

IF

IHC

ICC

FC

ELISA

ChIP

1:1000-1:5000

1:50-1:200

1:50-1:200

1:50-1:200

1:50-1:200

1:10-1:100

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-

Name

PBR Rabbit Monoclonal Antibody

Category

Rabbit Monoclonal Antibody (RabMAb); Primary antibody

Isotype

IgG

Purification

Affinity purification

Immunogen

Recombinant protein

Gene ID

706(Human); 12257(Mouse)

SwissProt

P30536(Human); P50637(Mouse)

Synonyms

DBI; IBP; MBR; PBR; PBS; BPBS; BZRP; PKBS; PTBR; mDRC; pk18

Category

Apoptosis; Metabolism

Background

Mitochondrial peripheral-type benzodiazepine receptor (PBR) is an indispensable element of the steroidogenic machinery, where it mediates the delivery of cholesterol to the inner mitochondrial side chain cleavage cytochrome P-450 upon ligand activation. PBR is composed of three subunits, an isoquinoline binding site, a voltage-dependent anion channel and an adenine nucleotide carrier. PBR is genetically conserved from bacteria to humans and in humans is widely expressed in peripheral organs, whereas in the brain, it is sparse and located mainly in glial cells. Peroxisome proliferator perfluordecanoic acid (PFDA) inhibits the Leydig cell steroidogenesis by affecting PBR mRNA stability, thus inhibiting PBR expression, cholesterol transport into the mitochondria and subsequent steroid formation. A cytoplasmic protein, PRAX-1 ( peripheral benzodiazepine receptor-associated protein 1), is found to specifically interact with PBR. The polypeptide diazepam binding inhibitor is an endogenous PBR ligand. PBR also binds Ro 5-4864 (4' -chlorodiazepam) and PK 11185 (an isoquinoline carboxamide derivative), but not clonazepam, and PBR regulates the cholesterol transport that results in decreased circulating corticosterone levels.

产品编号

产品名称

包装

AF1024

PBR Rabbit Monoclonal Antibody

50μl

AZ050

Western一抗稀释液

50ml

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说明书

1份