辣椒平-C-120

一、产品概述

二、产品信息

A Selective TRPV1 Blocker and an Activator of ENaCγ Channels;Capsazepine (#C-120) is a highly pure, synthetic, and biologically active compound.

三、背景

Capsazepine is a synthetic, competitive and selective antagonist of TRPV1 (transient receptor potential vanilloid 1)1 and an activator of amiloride-sensitive epithelial Na+ channel gamma (ENaCγ). It also inhibits K+-dependent ATP hydrolysis with no effect on Na+-ATPase2,3.
Capsazepine is being used in in vitro and in vivo pharmacological studies as a standard TRPV1 competitive antagonist.
Capsazepine exhibits potent inhibition of expression of the iNOS gene in LPS-stimulated murine macrophages through inactivation of NF-κB4.
The amiloride-sensitive epithelial Na+ channel (ENaC) regulates Na+ homeostasis into cells and across epithelia5.
TRPV1 is a member of a distinct subgroup of transient receptor potential (TRP) ion channels. These channels are highly expressed on primary nociceptors and can be activated by several different stimuli such as heat, acid, certain arachidonic acid derivatives and direct phosphorylation via PKC6.

四、制备和贮存

五、产品特点

六、注意事项