| 名称 | Grepafloxacin |
| 描述 | Grepafloxacin (OPC-17116) is a fluoroquinolone antibiotic that is administered orally. It possesses strong efficacy against community-acquired respiratory pathogens, notably Streptococcus pneumonia. Grepafloxacin exhibits excellent tissue penetration and demonstrates a promising pharmacodynamic profile. |
| 体外活性 | Grepafloxacin is a once-daily fluoroquinolone[2]. Grepafloxacin exhibits potent in vitro antibacterial activity against Gram-positive bacteria such as Streptococcus pneumoniae and high in vivo efficacy on the experimental systemic infections caused by the Gram-positive and -negative bacteria tested[4]. |
| 体内活性 | Grepafloxacin (OPC-17116) (200 mg/kg; p.o.; Balb/c mice) displays good safety profile in terms of phototoxicity[2]. Grepafloxacin (p.o.; 25, 50, 100, and 200 mg/kg; 5 days/week for 4 weeks; Female C57BL6/J-Lyst bg-J/ mice/beige mice) has modest activities in both intranasal (IN) infection and intravenous (IV) Mycobacterium avium infection models[3]. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| 关键字 | OPC17116 | OPC 17116 | Grepafloxacin |
| 相关产品 | Adipic dihydrazide | Levulinic acid | Doxycycline | Neomycin sulfate | Terbinafine hydrochloride | BES | Sodium bicarbonate | Hyaluronic acid sodium (MW 20 kDa) | Sodium diacetate | Sulfamethoxazole sodium | Kanamycin sulfate | D(+)-Raffinose pentahydrate |
