短杆菌肽A/1405-97-6/Gramicidin A

Product Name：Gramicidin A

CAS No.：1405-97-6

Synonyms：短杆菌肽A

Catalog No.：218P141

Brand：Typeptide Biotech（肽研生物）

Description：Gramicidin A是由短芽孢杆菌产生的一种抗生素，为线状十五肽，N端甲酰化封闭氨基，C端是醛基。Gramicidin A能够杀死某些微生物．两个短杆菌肽A分子从膜两侧相对插入可形成穿膜通道，提高生物膜对某些一价阳离子的通透性，使这些物质顺浓度梯度通过细胞膜，不过Gramicidin A并不显著提高运输速度。研究显示Gramicidin A能抑制T7噬菌体DNA的转录，抑制膜结合的表皮腺苷酸三磷酸酶活性和体外阻抑人淋巴细胞转化。在大鼠动物模型中能延长心脏移植存活率。

Gramicidin A is an antibiotic produced by Bacillus brevis, which is a linear pentadecapeptide with an N-terminal formylated blocked amino group and a C-terminal aldehyde group. Gramicidin A can kill certain microorganisms. Two molecules of gramicidin A insert from opposite sides of the membrane to form a transmembrane channel, enhancing the permeability of biological membranes to certain monovalent cations and allowing these substances to pass through the cell membrane along the concentration gradient. However, gramicidin A does not significantly increase transport speed. Studies have shown that gramicidin A inhibits the transcription of T7 phage DNA, suppresses membrane-bound epidermal adenosine triphosphatase activity, and blocks the transformation of human lymphocytes in vitro. In rat animal models, it can prolong the survival rate of heart transplants.

Purity (HPLC) ≥98.0%

Single impurity≤2%

Peptide content≥75.0%

Amino Acid Composition≤±15%

Bacterial Endotoxins≤50EU/mg

Solubility：H₂O/DMSO

Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.

Storage:Cool dry place( Store at -20°C, away from the light)

Remark:For Research Use Only. Not for human use.

订购联系方式：

南京肽研生物生物科技有限公司

手机号：19961912513(微信同号)

QQ: 2178255659

邮箱：sales@typeptide.com

联系人：顾经理

申明：本产品仅供科研使用，不得用于人体。