2-[3-(6-甲基-2-吡啶基)-1H-吡唑-4-基]-1,5-萘啶 (ALK 5抑制剂II) RepSox (ALK5 Inhibitor II) 新品

英文名称: RepSox (Synonyms: E-616452; SJN 2511;ALK5 Inhibitor II)

中文名称: 2-[3-(6-甲基-2-吡啶基)-1H-吡唑-4-基]-1,5-萘啶 (ALK 5抑制剂II)

CAS号: 446859-33-2

分子式: C17H13N5

分子量: 287.32

MDL: MFCD09037561

外观: Light brown to yellow powder

储存条件: Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

RepSox (E-616452) is a cell permeable, selective inhibitor of the TGF-β type 1 activin like kinase receptor ALK5 (IC50s = 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-β cellular assay, and ALK5 binding in HepG2 cells, respectively). This inhibitor demonstrated less potent activity (IC50s > 16 μM) when tested against a panel of 9 related kinases, including p38 MAPK and GSK3. At 25 μM, this compound has been used to induce stem cell pluripotency by replacing the reprogramming transcription factor Sox2 via inhibition of the TGF-β signaling pathway and induction of Nanog transcription.

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