化合物 MC1568|T2023|TargetMol

MC1568
852475-26-4

￥257 5mg 起订

￥413 10mg 起订

￥739 25mg 起订

上海更新日期：2024-09-30

TargetMol中国（陶术生物）

VIP3年

联系人：邵小姐

手机：4008200310 拨打

邮箱：marketing@tsbiochem.com

产品详情:

中文名称：: 化合物 MC1568

英文名称：: MC1568

CAS号：: 852475-26-4

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: ≥95%

产品类别：: 抑制剂

货号：: T2023

Product Introduction

Bioactivity

名称	MC1568
描述	MC1568 is a specific HDAC inhibitor for maize HD1-A (IC50: 100 nM, in a cell-free assay). It is 34-fold more selective for HD1-A than HD1-B.
细胞实验	The 3T3-L1 cells are propagated and differentiated using a cocktail of isobutylmethylxanthine, dexamethasone, and insulin. From the second day post-confluence and throughout the differentiation period of 8 days, the 3T3-L1 cells are induced by: (1) no induction: at post-confluence and throughout the differentiation period of 8 days, the cells are incubated with DMSO or MC1568. (2) troglitazone: at post-confluence and throughout the differentiation period of 8 days, the cells are induced with 5 μM troglitazone, MC1568, or both. (3) rosiglitazone: at post-confluence and throughout the differentiation period of 8 days, the cells are incubated with 1?μM rosiglitazone and either DMSO or MC1568. (4) rosiglitazone and dexamethasone: at post-confluence, the cells received 1?μM of rosiglitazone and 390?ng/mL dexamethasone. Throughout the differentiation period of 8 days, the cells are induced with 1?μM of rosiglitazone and either DMSO or MC1568. All medium is renewed every second day.(Only for Reference)
激酶实验	Maize HD2, HD1-B, and HD1-A Enzyme Inhibition.: The enzyme liberats tritiated acetic acid from the substrate, which is quantified by scintillation counting. IC50 values are results of triple determinations. A 50 μL sample of maize enzyme (at 30 °C) is incubated (30 min) with 10 μL of total [3H]acetate-prelabeled chicken reticulocyte histones (2 mg/mL). Reaction is stopped by addition of 50 μL of 1 M HCl/0.4 M acetate and 800 μL of ethyl acetate. After centrifugation (1×104 g, 5 min), an aliquot of 600 μL of the upper phase is counted for radioactivity in 3 mL of liquid scintillation cocktail. MC1568 is tested at a starting concentration of 40 μM, and active substances are diluted further. NaB, VPA, TSA, SAHA, 85 TPX, HC-toxin, and tubacin are used as the reference compounds, and blank solvents are used as negative controls.
体外活性	在胰脏移植研究中,MC1568增强内分泌β和δ-cells细胞,并使Pax4的表达增强. 在鼠体内,MC1568（50 mg/kg）组织选择性地显著抑制HDAC. 在PPRE-Luc鼠体内,MC1568（50 mg/kg）主要损害心脏和脂肪组织部位PPARγ信号.作用于骨骼肌和心脏时,MC1568抑制HDAC4/5的活性,不影响HDAC3活性,故MEF2-HDAC复合体处于未激活状态.
体内活性	MC1568对HDAC II的选择性抑制效果（IC50：220 nM）是I型的176倍。作用于C2C12细胞时,MC1568（5 μM）通过降低肌细胞增强因子2D的表达,使HDAC4-HDAC3-MEF2D复合体稳定,并抑制分化诱导的MEF2D乙酰化,从而使肌细胞生成被阻断。MC1568（5或10 μM）可使RAR和PPARγ调节的分化诱导信号通路受干扰。在MCF-7细胞中,MC1568（20 μM）使乙酰化H3和H4组蛋白的累积增强,并提高乙酰基微管蛋白的水平,表明MC1568可抑制HDAC6。作用于人类乳腺癌ZR-75.1细胞裂解物时,MC1568对HDAC1无抑制作用,但是可使HDAC4受抑制。作用于F9细胞时,MC1568选择性抑制内胚分化,对VA诱导的早幼粒NB4细胞成熟无影响。作用于3T3-L1细胞时,MC1568使PPARγ诱导的脂肪生成降低。
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	H2O : < 1 mg/mL (insoluble or slightly soluble) Ethanol : < 1 mg/mL (insoluble or slightly soluble) DMSO : 11 mg/mL (35 mM)
关键字	HDAC \| Histone deacetylases \| inhibit \| MC-1568 \| Inhibitor \| MC1568 \| MC 1568
相关产品	Valproic acid sodium salt \| 4-Phenylbutyric acid \| Valproic Acid \| Panobinostat \| Methyl L-histidinate dihydrochloride \| Theophylline \| Acefylline \| Curcumin \| Theophylline monohydrate \| Sodium 4-phenylbutyrate \| Vorinostat \| Parthenolide
相关库	抑制剂库 \| 抗乳腺癌化合物库 \| 经典已知活性库 \| 已知活性化合物库 \| 自噬库 \| 染色质修饰分子库 \| 含氟化合物库 \| 抗衰老化合物库 \| 表观遗传库 \| NF-κB 通路分子库

MC1568|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期	(12年)
注册资本	566.265100万人民币
员工人数	100-500人
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主营行业	天然产物,生化试剂,分子生物学,分子砌块,生物技术服务