化合物 LY2886721|T6058|TargetMol

LY2886721
1262036-50-9

￥170 1mg 起订

￥398 5mg 起订

￥678 10mg 起订

上海更新日期：2024-09-30

TargetMol中国（陶术生物）

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联系人：邵小姐

手机：4008200310 拨打

邮箱：marketing@tsbiochem.com

产品详情:

中文名称：: 化合物 LY2886721

英文名称：: LY2886721

CAS号：: 1262036-50-9

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 99.94%

产品类别：: 抑制剂

货号：: T6058

Product Introduction

Bioactivity

Name	LY2886721
Description	LY2886721, a BACE inhibitor, is used for the therapy of Alzheimer's Disease.
Kinase Assay	The CTLs and NK cells (0.8×106/mL) are treated with the inhibitors L1 (10-20 μM) or Aloxistatin (20-30 μM) for 24 hr at 37°C in 24-well plates. Cells are then used in 51Cr-release assays or are lysed to examine perforin in Western blots. The inhibitor is also added at the same concentration during the 4 hr reactions in some 51Cr-release assays, as indicated. Cell lysates are prepared using NP-40 lysis buffer (25 mM HEPES, 250 mM NaCl, 2.5 mM ethylenediaminetetraacetic acid, 0.1% volume/volume Nonidet P-40) and total protein concentration is determined using the Bradford assay. Equal amounts of protein are loaded and resolved on 8% SDS-PAGE gels. Human or mouse perforin is detected using the appropriate antibodies as indicated. Anti-actin antibody is used as a loading control[2].
In vitro	LY2886721 is an oral, small molecule of β-site amyloid protein cleaving enzyme (BACE) inhibitor with the potential to inhibit the synthesis of β-amyloid and thereby to slow the Clinicalal progression of AD. [1] LY2886721 can also targetγ-secretase to nhibit the synthesis of β-amyloid. [2]
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	Ethanol : < 1 mg/mL (insoluble or slightly soluble) H2O : < 1 mg/mL (insoluble or slightly soluble) DMSO : 1 mg/ml, Sonication is recommended.
Keywords	BACE2 \| Inhibitor \| BACE \| Beta-secretase \| BBB \| Alzheimer's \| BACE1 \| sAPPβ \| LY 2886721 \| LY2886721 \| C99 \| LY-2886721 \| inhibit \| disease \| β-Secretase
Inhibitors Related	Loganin \| Epiberberine \| Aloeresin D \| Phytic acid potassium \| NB-360 \| Atabecestat \| Auraptene \| Verubecestat \| Eslicarbazepine Acetate \| Tenuifolin \| DSS30 \| Timosaponin BII
Related Compound Libraries	Inhibitor Library \| CNS-Penetrant Compound Library \| Bioactive Compound Library \| Bioactive Compounds Library Max \| ReFRAME Related Library \| Anti-Cardiovascular Disease Compound Library \| Protease Inhibitor Library \| Anti-Neurodegenerative Disease Compound Library \| Orally Active Compound Library \| Drug Repurposing Compound Library

LY2886721|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期	(12年)
注册资本	566.265100万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,工厂,试剂,定制,服务
主营行业	天然产物,生化试剂,分子生物学,分子砌块,生物技术服务

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LY2886721, CAS #1262036-50-9
Shanghai Yusheng Medchem Co., Ltd
2023-06-02
询价

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