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  • 化合物 Loxapine hydrochloride|T61381|TargetMol

化合物 Loxapine hydrochloride|T61381|TargetMol

Loxapine hydrochloride
54810-23-0
17500 100mg 起订
13800 50mg 起订
10600 25mg 起订
上海 更新日期:2025-11-17

TargetMol中国(陶术生物)

VIP4年
联系人:邵小姐
手机:4008200310 拨打
邮箱:marketing@tsbiochem.com

产品详情:

中文名称:
化合物 Loxapine hydrochloride
英文名称:
Loxapine hydrochloride
CAS号:
54810-23-0
品牌:
TargetMol
产地:
美国
保存条件:
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
产品类别:
抑制剂
货号:
T61381

Product Introduction

Bioactivity

名称Loxapine hydrochloride
描述Loxapine hydrochloride is a dibenzoxazepine anti-psychotic agent that exerts its effects through oral administration, functioning as an inhibitor of dopamine and an antagonist of 5-HT receptors [1] [4].
体外活性In the presence of Loxapine, [ 3 H]ketanserin binds to 5-HT 2 receptor in Frontal cortex of brain in human and bovine with K i value of 6.2 nM and 6.6 nM, respectively. Loxapine has the rank order of potency for the various receptors appears to be as follows: 5-HT 2 ≥D 4 >>>D 1 >D 2 in comparing competition experiments involving the human membranes [1]. Loxapine (0-20 μM, 24 h or 72 h) reduces IL-1β secretion by LPS-activated mixed glia cultures, reduces IL-2 secretion in mixed glia cultures, and decreases IL-1β and IL-2 secretion in LPS-induced microglia cultures [2].
体内活性Loxapine (5 mg/kg; i.p.; daily for 4 or 10 weeks) decreases serotonin (S 2 ) but does not elevate dopamine (D2) receptor numbers in the rat brain [3]. Animal Model: Adult male Wistar rats (150-175 g) [3] Dosage: 5 mg/kg Administration: Intraperitoneal injection, daily for 4 or 10 weeks Result: Induced a very significant reduction (more than 50%) of serotonin (S 2 ) receptor density after 4 weeks or 10 weeks of daily injection, but did not produce any significant increase in dopamine receptor density.
存储条件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
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Loxapine hydrochloride|TargetMol

公司简介

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿,致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区,已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库,以及多种类型的生化试剂产品,包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等,此外,我们还建设有CADD(计算机辅助药物设计)研究中心、药理实验室、药化合成平台三大技术中心,全方位满足客户的定制需求。 凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持,我们将有效帮助您缩短研发周期,取得更成功的结果。

成立日期 (13年)
注册资本 566.265100万人民币
员工人数 100-500人
年营业额 ¥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生化试剂,分子生物学,分子砌块,生物技术服务

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