化合物 KU-60019|T2474|TargetMol

KU60019
925701-49-1

￥297 1mg 起订

￥710 5mg 起订

￥990 10mg 起订

上海更新日期：2024-12-12

TargetMol中国（陶术生物）

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联系人：邵小姐

手机：4008200310 拨打

邮箱：marketing@tsbiochem.com

产品详情:

中文名称：: 化合物 KU-60019

英文名称：: KU60019

CAS号：: 925701-49-1

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 99%

产品类别：: 抑制剂

货号：: T2474

Product Introduction

Bioactivity

Name	KU60019
Description	Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC50: 6.3 nM). It is much less effective or without effect against a panel of 229 other kinases.
Cell Research	Cell growth was determined by AlamarBlue. U1242 cells were serially diluted, allowed to attach for 6 h and then exposed to KU-60019 at 3 μM. At days 1, 3 and 5 after seeding, AlamarBlue was added to the medium to the recommended final concentration. Plates were incubated for 1 h at 37°C and fluorescence determined on a FluoroCount plate reader (excitation 530 nm, emission 590 nm) and values taken as a measure of cell growth [1].
Animal Research	Cells (3 × 10^7) were implanted into male Fox Chase Severe Combined Immunodeficiency (SCID) mice. Administration of doxycycline was started when tumors reached 100 mm3 in volume and was performed every 48 hours up to removal of the animal from the experiment. Forty-eight hours after PTEN induction, animals were administered KU-60019 (100 mg/kg) for 5 consecutive days and measured until they reached a target 400 mm3 volume. Measurements of tumor volume and body weight took place every 3 days using calipers [3].
In vitro	KU-60019是ATM激酶的一种改良型抑制剂，其IC50值为6.3 nM，大约是KU-55933的一半。对于DNA-PKcs和ATR的IC50值分别为1.7和>10 μM，分别是对ATM的近270倍和1600倍[1]。KU-60019在300 nM的浓度下，可以在应用后最快15分钟内完全抑制p53和H2AX的磷酸化。当U1242细胞经KU-60019处理1小时后，洗去KU-60019再经IR挑战，KU-60019的抑制效果在洗去后最早的15分钟内即被逆转[2]。
In vivo	尽管PTEN缺失型对照肿瘤在PTEN野生型对照前达到了4倍的体积增长，但经KU-60019处理的PTEN缺失型肿瘤显示出了统计学上的显著生长减缓，这种生长抑制在实验开始阶段（第5-12天）尤为明显，正好是在给予KU-60019治疗后（第1-5天）[3]。当使用渗透泵给予KU-60019处理并随后对携带U1242/luc-GFP肿瘤的小鼠进行2 Gy辐射照射时，我们通过生物发光成像（BLI）在辐射后第7天，即第20天成功证明了肿瘤细胞的完全消除[4]。
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 50 mg/mL (91.3 mM), Sonication is recommended. H2O : < 1 mg/mL (insoluble or slightly soluble) Ethanol : < 1 mg/mL (insoluble or slightly soluble)
Keywords	KU60019
Inhibitors Related	Schisandrin B \| Ceralasertib \| AZ31 \| Berzosertib \| Elimusertib \| CP-466722 \| AZ20 \| GJ103 sodium salt \| Ro 90-7501 \| NU6027 \| (Z)-Mirin \| Dactolisib
Related Compound Libraries	Bioactive Compound Library \| Bioactive Compounds Library Max \| Oxidation-Reduction Compound Library \| Kinase Inhibitor Library \| Anti-Aging Compound Library \| HIF-1 Signaling Pathway Compound Library \| Cancer Cell Differentiation Compound Library \| Glycometabolism Compound Library \| Tyrosine Kinase Inhibitor Library \| Target-Focused Phenotypic Screening Library

KU-60019|||KU 60019|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期	(12年)
注册资本	566.265100万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,工厂,试剂,定制,服务
主营行业	天然产物,生化试剂,分子生物学,分子砌块,生物技术服务