硫代乙基氨基乙基胺盐酸盐|TQ0133|TargetMol
Amifostine thiol dihydrochloride
14653-77-1
14653-77-1
¥117
1mg
起订
¥277
5mg
起订
¥453
10mg
起订
上海 更新日期:2025-02-28
产品详情:
- 中文名称:
- 硫代乙基氨基乙基胺盐酸盐
- 英文名称:
- Amifostine thiol dihydrochloride
- CAS号:
- 14653-77-1
- 品牌:
- TargetMol
- 产地:
- 美国
- 保存条件:
- Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
- 纯度规格:
- 100%
- 产品类别:
- 抑制剂
- 货号:
- TQ0133
Product Introduction
Bioactivity
名称 | Amifostine thiol dihydrochloride |
描述 | Amifostine thiol dihydrochloride (WR 1065) can activate p53 through a JNK-dependent signaling pathway. It also protects normal tissues from the toxic effects of certain cancer drugs. |
细胞实验 | For Western analysis, cells are treated with 1 mM WR-1065 for 24 h, and subconfluent cultures of cells are harvested and lysed in RIPA buffer supplemented with protease inhibitors. Protein concentrations are determined by a detergent-compatible assay. Western blots are blocked and incubated in antibody in PBS/0.2% Tween 20/5% nonfat dry milk. Blots are incubated with 1 μg/mL antibody for 1 h at room temperature, followed by washing in PBS/0.2% Tween 20 and incubation in peroxidase-conjugated secondary antibody and chemiluminescence detection [2]. |
动物实验 | Seventy-two rats are divided randomly into 9 equal groups: 1) Control group receives no injection and is left untreated for the entire period of the experiment as intact animals; 2) Sham-operated group is subjected only to surgical procedure; 3) Vehicle (saline)-treated group receives 2 μL saline (Intra-SNc); 4) Lesioned group receives 6-hydroxydopamine; 5) Vehicle+6OHDA group receives saline as a vehicle 3 days once daily (2 μL/rat) before 6-OHDA injection; 6 to 8) Rats in these groups are pretreated with Intra-SNc injection of WR-1065 (20, 40 and 80 μg/2 μL/rat) 3 days before 6-OHDA injection; 9) Non-lesioned animals receive intra-SNc injection of WR-1065 dihydrochloride (80 μg/2 μL/rat) for three days [3]. |
体外活性 | The DNA-binding activity is increased in a WR-1065 concentration-dependent manner. Cells treated with 1 mM WR-1065 dihydrochloride for 24 h revealed that all of the p53-induced genes analyzed are transactivated following WR-1065 dihydrochloride treatment, in a p53-dependent manner. Significantly, treatment with WR-1065 dihydrochloride leads to a 3-fold increase in luciferase expression driven by AP-1 and a 5-fold increase when this reporter gene is driven by NF-κB when these values are normalized to the level of the cotransfected β-galactosidase gene [2]. |
体内活性 | WR-1065 attenuates the severity of 6-OHDA-induced catalepsy when compared with 6-OHDA-lesioned rats. Also, it has been observed that WR-1065 dihydrochloride improves catalepsy in a dose-dependent manner. Pretreatment with three different doses of WR-1065 dihydrochloride (20, 40, and 80 μg/2 μL/rat) for 3 days before 6-OHDA administration, significantly elevates SOD activity and restores it to normal range compare with 6-OHDA lesioned rats [3]. |
存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 24 mg/mL (115.85 mM), Sonication is recommended. H2O : 100 mg/mL (482.72 mM) |
关键字 | Amifostine thiol | WR-1065 | Amifostine thiol dihydrochloride | Inhibitor | MDM-2/p53 | Amifostine thiol Dihydrochloride | WR1065 | inhibit |
相关产品 | MMRi64 | Roslin 2 bromide | P53R3 | Eprenetapopt | XI-006 | Pifithrin-μ | Rotenone | BAY 1892005 | DPBQ | Indole-3-carbinol | CT-1 | RITA |
相关库 | 经典已知活性库 | 抗癌活性化合物库 | 已知活性化合物库 | 转录因子库 | 抗胰腺癌化合物库 | 抗衰老化合物库 | 泛素化化合物库 |
硫代乙基氨基乙基胺盐酸盐|||WR 1065|TargetMol
公司简介
TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿,致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区,已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库,以及多种类型的生化试剂产品,包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等,此外,我们还建设有CADD(计算机辅助药物设计)研究中心、药理实验室、药化合成平台三大技术中心,全方位满足客户的定制需求。 凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持,我们将有效帮助您缩短研发周期,取得更成功的结果。
成立日期 | (12年) |
注册资本 | 566.265100万人民币 |
员工人数 | 100-500人 |
年营业额 | ¥ 1亿以上 |
经营模式 | 贸易,工厂,试剂,定制,服务 |
主营行业 | 天然产物,生化试剂,分子生物学,分子砌块,生物技术服务 |
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