硫代乙基氨基乙基胺盐酸盐
硫代乙基氨基乙基胺盐酸盐 性质
| 熔点 | 184-186°C |
|---|---|
| 储存条件 | -20°C |
| 溶解度 | H2O：≥20mg/mL |
| 形态 | 粉末 |
| 颜色 | 白色至类白色 |
| 水溶解性 | H2O: ≥20mg/mL |
| 稳定性 | 吸湿性 |
| InChI | InChI=1S/C5H14N2S/c6-2-1-3-7-4-5-8/h7-8H,1-6H2 |
| InChIKey | YHPLKWQJMAYFCN-UHFFFAOYSA-N |
| SMILES | NCCCNCCS |
硫代乙基氨基乙基胺盐酸盐 用途与合成方法
p53
The DNA-binding activity is increased in a WR-1065 dihydrochloride (WR-1065) concentration-dependent manner. Cells treated with 1 mM WR-1065 dihydrochloride for 24 h reveal that all of the p53-induced genes analyzed are transactivated following WR-1065 dihydrochloride treatment, in a p53-dependent manner. Significantly, treatment with WR-1065 dihydrochloride leads to a 3-fold increase in luciferase expression driven by AP-1, and a 5-fold increase when this reporter gene is driven by NF-κB, when these values are normalized to the level of the cotransfected β-galactosidase gene.
The results show that wR-1065 dihydrochloride (WR-1065) attenuates the severity of 6-OHDA-induced catalepsy (P<0.001) when compare with 6-OHDA-lesioned rats. Also it has been observed that WR-1065 dihydrochloride improves catalepsy in dose dependent manner (P<0.001). Pretreatment with three different doses of WR-1065 dihydrochloride (20, 40 and 80 μg/2 μL/rat) for 3 days before 6-OHDA administration, significantly (P<0.001) elevates SOD activity and restores it to normal range compare with 6-OHDA lesioned rats.
安全信息
| 危险品标志 | Xn |
|---|---|
| 危险类别码 | 22-41 |
| 安全说明 | 26-39-41 |
| WGK Germany | 3 |
| 海关编码 | 2930909165 |
| 存储类别 | 11 - 可燃固体 |
| 危险性类别 | 急性毒性 类别4 经口 严重眼损伤 类别1 |
| 毒性 | mouse,LD50,intraperitoneal,400mg/kg (400mg/kg),European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 24, Pg. 48, 1989. |
硫代乙基氨基乙基胺盐酸盐 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-103640R | 硫代乙基氨基乙基胺盐酸盐 | 14653-77-1 | 5 mg | 1200 |
| 2026-09-15 | HY-103640 | 硫代乙基氨基乙基胺盐酸盐 | 14653-77-1 | 1 mg | 140 |
