化合物 ON123300|T6920|TargetMol

ON123300
1357470-29-1

￥343 1mg 起订

￥496 2mg 起订

￥818 5mg 起订

上海更新日期：2024-09-29

TargetMol中国（陶术生物）

VIP3年

联系人：邵小姐

手机：4008200310 拨打

邮箱：marketing@tsbiochem.com

产品详情:

中文名称：: 化合物 ON123300

英文名称：: ON123300

CAS号：: 1357470-29-1

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 99.53%

产品类别：: 抑制剂

货号：: T6920

Product Introduction

Bioactivity

Name	ON123300
Description	ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRβ/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM).
Kinase Assay	CDK1 kinase activity is tested by the CDK1/cyclin B complex purified from baculovirus to phosphorylate a biotinylated peptide substrate containing the consensus phosphorylation site for histone H1, which is phosphorylated in vivo by CDK1. Inhibition of CDK1 activity is measured by observing a decreased amount of 33P-γ-ATP incorporation into the immobilized substrate in streptavidin-coated 96-well scintillating microplates. CDK1 enzyme is diluted in 50 mM Tris-HCl (pH 8), 10 mM MgCl2, 0.1 mM Na3VO4, 1 mM DTT, 1% DMSO, 0.25 μM peptide, 0.1 μCi per well 33P-γ-ATP, and 5 μM ATP in the presence or absence of various concentrations of JNJ-7706621 and incubated at 30 °C for 1 hour. The reaction is terminated by washing with PBS containing 100 mM EDTA and plates are counted in a scintillation counter. IC50 is determined by Linear regression analysis of the percent inhibition by JNJ-7706621.
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	Ethanol : < 1 mg/mL (insoluble or slightly soluble) H2O : < 1 mg/mL (insoluble or slightly soluble) DMSO : ＜1 mg/mL (insoluble or slightly soluble)
Keywords	Platelet-derived growth factor receptor \| ON123300 \| AMP-activated protein kinase \| FGFR1 \| kinase \| brain \| CDK \| Ark5 \| U87 \| inhibit \| PDGFR \| multi \| RET \| tumor \| Inhibitor \| glioma \| Cyclin dependent kinase \| AMPK \| CDK4 \| FYN \| RTK \| penetration \| PDGFRβ \| ON-123300 \| CDK6 \| ON 123300
Inhibitors Related	Chitosan oligosaccharide \| Amlexanox \| Formononetin \| Ferulic Acid \| Regorafenib \| Pazopanib \| Sorafenib \| Metformin hydrochloride \| Adenosine monophosphate \| Ruxolitinib phosphate \| Abemaciclib \| Methyl cinnamate
Related Compound Libraries	Inhibitor Library \| Bioactive Compound Library \| Anti-Cancer Active Compound Library \| Bioactive Compounds Library Max \| Kinase Inhibitor Library \| Membrane Protein-targeted Compound Library \| Drug Repurposing Compound Library \| Tyrosine Kinase Inhibitor Library \| Anti-Cancer Clinical Compound Library \| Anti-Cancer Drug Library

ON123300|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期	(12年)
注册资本	566.265100万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,工厂,试剂,定制,服务
主营行业	天然产物,生化试剂,分子生物学,分子砌块,生物技术服务

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