酮麝香|T5654|TargetMol

Musk ketone
81-14-1

￥435 500mg 起订

￥196 100mg 起订

￥122 50mg 起订

上海更新日期：2024-12-02

TargetMol中国（陶术生物）

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联系人：邵小姐

电话：021-021-33632979拨打

手机：15002134094 拨打

邮箱：marketing@targetmol.com

产品详情:

中文名称：: 酮麝香

英文名称：: Musk ketone

CAS号：: 81-14-1

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 99.85%

产品类别：: 抑制剂

货号：: T5654

Product Introduction

Bioactivity

名称	Musk ketone
描述	Musk ketone can induce the growth repression and the apoptosis of cancer cells. Musk ketone increases activity of glutathione S-transferase and thus may prove to be useful cancer chemoprotectant.
细胞实验	Twenty two cancer cell lines were treated with musk. Cell proliferation and apoptosis analyses were carried out. Native musk and synthetic?musk ketone?were analyzed by gas chromatograph-mass spectrometer (GC-MS) assay. Differentially expressed genes were determined by microarray and quantitative real-time polymerase chain reaction.
动物实验	The rats weighed from 200 to 250 g and ?were randomly divided into five treatment groups: saline (NS group), methylprednisolone (MP group), and musk ketone groups (MO1, MO2, and MO3 groups).?The Swash plate test and BBB behavioral score were used to determine neurological function recovery after spinal cord injury.?Hematoxylin-eosin (HE) staining was used to detect general structural changes in spinal cord tissue.?The enzyme-linked immunosorbent assay was used for the determination of interleukin 10 (IL-10) in spinal cord tissue.??Compared with the NS control group, critical angle, BBB score and IL-10 levels in rat spinal cord tissue significantly increased in the MP group and MO groups 7 and 14 days after the operation.?HE staining showed that in the NS group, there was hemorrhage, edema, necrosis, axonal demyelination, inflammatory cell infiltration and glial cell response in spinal cord tissue.?After 7 days, spinal cord edema and inflammation were reduced and neuronal degeneration and necrosis were not evident in the MP and MO groups[2].
体外活性	类似于天然麝香，合成Musk ketone抑制了癌细胞的生长并促进了其凋亡。此外，天然麝香处理后的肺癌细胞中许多基因表达发生了变化，这些差异表达的基因涉及多个信号传导途径。在这些信号途径中，与凋亡相关的途径包括白细胞介素家族、肿瘤坏死因子家族和MAPK信号途径。天然麝香和合成Musk ketone能够在肺癌细胞中上调IL-24（白细胞介素家族）和DDIT3（MAPK信号途径）[1]。
体内活性	Musk ketone可减少脊髓损伤后的次生损害，并促进大鼠神经恢复[2]。
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 25 mg/mL (84.95 mM)
关键字	Apoptosis \| inhibit \| Hep G2 \| PI3K/Akt \| Musk ketone \| neuroprotective \| Protein kinase B \| Inhibitor \| PKB \| cerebral ischemia \| PI3K \| Akt \| Phosphoinositide 3-kinase
相关库	神经保护化合物库 \| 抗癌活性化合物库 \| 经典已知活性库 \| 已知活性化合物库 \| 抗癌天然产物库 \| 天然产物库 \| 化妆品成分化合物库 \| 高通量筛选天然产物库

酮麝香|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(12年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子