泊马度胺|T2384|TargetMol

Pomalidomide
19171-19-8

￥429 10mg 起订

￥644 50mg 起订

￥831 100mg 起订

上海更新日期：2024-09-23

TargetMol中国（陶术生物）

VIP12年

联系人：邵小姐

电话：021-021-33632979拨打

手机：15002134094 拨打

邮箱：marketing@targetmol.com

产品详情:

中文名称：: 泊马度胺

英文名称：: Pomalidomide

CAS号：: 19171-19-8

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 98.8%

产品类别：: 抑制剂

货号：: T2384

Product Introduction

Bioactivity

名称	Pomalidomide
描述	Pomalidomide (CC-4047) is an anti-angiogenic and immunomodulatory agent. Pomalidomide is a ligand for the ubiquitin E3 ligase cereblon (CRBN) and is commonly used in the synthesis of PROTAC products.
细胞实验	In vitro effects of either CC-5013 or CC-4047 as single agent or in combination with rituximab were evaluated by flow cytometric analysis. Lymphoma cell lines (1 × 10^6 cells) were exposed to either CC-5013 (5 μg/mL), CC-4047 (5 μg/mL), or vehicle control (DMRIE-C, 0.01%) alone or in combination with rituximab at a final concentration of 10 μg/mL. Following a period of incubation of 24 or 48 hours, apoptosis was assessed by staining-treated cells with FITC-labeled Annexin V and propidium iodine. All samples were analyzed by multicolor flow cytometric analysis using a fluorescence-activated cell sorter/FACStar Plus flow cytometer. Cells were scored as apoptotic if they were Annexin V–positive and propidium iodine–negative/positive (early and late apoptosis, respectively) [2].
激酶实验	TNF-α inhibitory activity is measured in lipopolysacharide (LPS) stimulated PBMC. Pomalidomide is added to human PBMCs 1 hour prior to the addition of LPS (1 μg/mL) and incubation continued for an additional 18-20 hours. Supernatants are then harvested, and the concentration of TNF-α in the supernatants is determined by ELISA. The concentration of Pomalidomide that IC50 is calculated by nonlinear regression analysis [1].
动物实验	These studies were carried out using a disseminated lymphoma-bearing SCID mouse xenograft model. Raji cells were harvested from confluent cultures and only suspensions with >90% viable cells were used for animal inoculation. Subsequently, on day 0, SCID mice received 1 ×10^6 Raji cells via i.v. Untreated SCID mice inoculated by i.v. injection develop symptomatic central nervous system, pulmonary, and liver metastasis that result in death from massive tumor burden and central nervous system involvement after 17 to 21 days after inoculation. A second lymphoma mouse model was used to address the significance of NK cell expansion in the biological interactions observed between rituximab and IMiDs. The second mouse lymphoma xenograft consisted of SCID mice depleted of NK cells bearing Raji cells implanted via tail vein injection as described above [2].
体外活性	方法: 多发性骨髓瘤细胞 RPMI8226 和 OPM2 用 Pomalidomide (0.01-50 µM) 处理 48 h，使用 MTT assay 检测细胞活力。结果: Pomalidomide 在 48 h 显著降低 RPMI8226 和 OPM2 细胞的细胞活力，IC50 值分别为 8 µM 和 10 µM。[1] 方法: 多发性骨髓瘤细胞 H929、U266 和 MM.1s 用 Pomalidomide (0.05-1 µM) 和 ACY-241 (3 µM) 处理 4 天，使用 Flow cytometry 检测细胞凋亡。结果: 当两种药物联合治疗时，相对于任何一种单一药物，细胞凋亡显著增加。[2]
体内活性	方法: 为评估在脑缺血中的潜在价值，将 Pomalidomide (50 mg/kg，1% carboxy methyl cellulose) 腹腔注射给长期过度表达 TNF-α 表面活性蛋白 (SP)-C 启动子的转基因小鼠 (SP-C/TNF-α 小鼠)，每天一次，持续 21 天。结果: Pomalidomide 显著降低血清 TNF-α 和 IL-5水平。[3]
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	H2O : < 1 mg/mL (insoluble or slightly soluble) DMSO : 50 mg/mL (182.99 mM) Ethanol : < 1 mg/mL (insoluble or slightly soluble) 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5.4 mg/mL (19.76 mM), Suspension. Working solution is recommended to be prepared and used immediately.
关键字	Ligands for E3 Ligase \| inhibit \| Apoptosis \| CC4047 \| Molecular Glues \| CC 4047 \| Inhibitor \| Pomalidomide \| E3 ligase-recruiting Moiety
相关产品	Stavudine \| L-Ascorbic acid \| Sodium 4-phenylbutyrate
相关库	抗癌活性化合物库 \| 经典已知活性库 \| 已知活性化合物库 \| 抗衰老化合物库 \| FDA 上市药物库 \| 药物功能重定位化合物库 \| 抗癌药物库

CC-4047|||泊马度胺|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(12年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子