化合物 AZD8055|T1859|TargetMol

AZD-8055
1009298-09-2

询价 1removed 起订

上海更新日期：2026-05-08

TargetMol中国（陶术生物）

VIP14年

联系人：邵小姐

电话：021-021-33632979拨打

手机：15002134094 拨打

邮箱：marketing@targetmol.com

产品详情:

中文名称：: 化合物 AZD8055

英文名称：: AZD-8055

CAS号：: 1009298-09-2

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

纯度规格：: 98.08%

产品类别：: 抑制剂

货号：: T001|T1859

Product Introduction

Bioactivity

名称	AZD-8055
描述	AZD-8055 is an orally bioavailable, highly selective, ATP-competitive mTOR kinase inhibitor that directly binds to the ATP-binding pocket of the mTOR kinase domain, while potently inhibiting both mTORC1 and mTORC2 complexes (IC₅₀ values of 0.8 nM and 0.1 nM, respectively). AZD-8055 is suitable for research in oncology, metabolic diseases, and fibrotic disorders.
细胞实验	For growth inhibition and acridine staining, cells were exposed to increasing concentrations of AZD8055 for 72 to 96 h and stained for cell nuclei (0.03 mg/mL Hoechst 33342) and acidic vesicles (1 μg/mL acridine orange). Images were captured at 450 and 536 nm on an ArrayScan II platform, and the percentage of acidic vesicles and the number of cells were quantified. For LC3 assessment, cells were exposed to e64d/pepstatin (10 μg/mL) for 30 to 90 min before incubation with AZD8055. Cells were lysed on ice and analyzed by immunoblotting [1].
激酶实验	The activity of mTOR was assayed using the recombinant mTOR technique described above. For inhibition experiments, AZD8055 was added to the reaction mixture and preincubated for 10 min before addition of ATP. Inhibition was performed at 1 to 3,000 nmol/L of AZD8055 in varying concentrations of ATP (40–200 μmol/L) [1].
动物实验	Tumor cells (10^6 for U87-MG, 5 × 10^6 for A549) were injected s.c. in a volume of 0.1 mL, and mice were randomized into control and treatment groups when tumor size reached 0.2 cm^3. AZD8055 was formulated in 30% (w/v) captisol (pH 3.0). The control group received the vehicle only. Tumor volumes (measured by caliper), animal body weight, and tumor condition were recorded twice weekly for the duration of the study. The tumor volume was calculated (taking length to be the longest diameter across the tumor and width to be the corresponding perpendicular diameter) using the following formula: (length × width) × √(length × width) × (π/6) [1].
体外活性	方法：Huh7 人肝癌细胞转染 HPCAL1 敲低（shRNA），转染后加入梯度浓度 AZD-8055 （0， 10， 50， 100， 500 nM），药物处理 72 小时，CCK-8 法检测细胞活力。结果：HPCAL1 敲低细胞对 AZD-8055 的敏感性增加（细胞活力更低）。[1] 方法：葡萄膜黑色素瘤细胞系：92.1， Mel202， MP38， MP41，加入 AZD-8055 （1 μM）和罗米地辛（25 ng/mL），罗米地辛处理 6 小时后更换新鲜培养基，继续培养至 48 小时，流式细胞术（Annexin V/SYTOX Green 染色）检测细胞凋亡。结果：AZD-8055 与罗米地辛联合在所有四种细胞系中均诱导了最高水平的凋亡，效果优于其他组合。[2]
体内活性	方法：通过 hydrodynamic tail-vein injection 构建的 MYC/Trp53⁻/⁻ 肝癌模型，同时使用 CRISPR/Cas9 敲除 Hpcal1(sgHpcal1)或对照(sgCON)，构建成功后腹腔注射 AZD-8055 (10 mg/kg/天，每日一次)，持续给药 30 天。结果：AZD-8055 治疗使 sgHpcal1 小鼠的肿瘤负荷显著降低，效果优于 sgCON 组。[1]
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
溶解度	Ethanol : 3 mg/mL (6.44 mM), Sonication is recommended. H2O : < 1 mg/mL (insoluble or slightly soluble) DMSO : 91 mg/mL (195.47 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4.5 mg/mL (9.67 mM), Solution.
关键字	mTOR \| Mammalian target of Rapamycin \| Inhibitor \| inhibit \| AZD-8055 \| AZD8055 \| AZD 8055 \| Autophagy \| Apoptosis
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AZD-8055;TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(14年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子