化合物 MYK-461|T7134|TargetMol

Mavacamten
1642288-47-8

￥289 1mg 起订

￥362 2mg 起订

￥496 5mg 起订

上海更新日期：2026-01-06

TargetMol中国（陶术生物）

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联系人：邵小姐

电话：021-021-33632979拨打

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邮箱：marketing@targetmol.com

产品详情:

中文名称：: 化合物 MYK-461

英文名称：: Mavacamten

CAS号：: 1642288-47-8

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

纯度规格：: 99.98%

产品类别：: 抑制剂

货号：: T7134

Product Introduction

Bioactivity

名称	Mavacamten
描述	Mavacamten (MYK-461) is an orally bioavailable inhibitor of cardiac myosin ATPase,( IC50s of 490, 711 nM for bovine cardiac and human cardiac, respectively)
动物实验	Five?cats received a combination of alfaxalone and midazolam for anesthetic induction, followed by inhaled isoflurane and oxygen maintenance.?Blood pressure was measured via an automated blood pressure cuff at five-minute intervals with supplementary continuous monitoring by arterial line when arterial access could be obtained.?Following induction of anesthesia, a complete baseline echocardiogram was performed (timepoint #1).?Cats were then treated with atropine 0.04 mg/kg IV, followed by an infusion of isoproterenol 0.04 μg/kg/min IV to elevate heart rate back to pre-anesthetized values and induce the previously observed LVOT obstruction.?After five to seven minutes, a stable heart rate of 200–220 bpm was reached and a complete echocardiogram was performed (timepoint #2).?At the completion of imaging, a ten-minute intravenous infusion of MYK-461 (n = 5) at 0.3 mg/kg/hr IV was started.?Focused echocardiography was performed after five minutes (timepoint #3).?After ten minutes, the MYK-461 infusion rate was lowered to 0.12 mg/kg/hr IV, a blood sample was drawn and an echocardiogram performed (timepoint #4).?If ventricular function remained hypercontractile or within normal limits by visual inspection, another blood sample was obtained and the MYK-461infusion rate was increased to 0.36 mg/kg/hr IV for ten minutes.?Focused echocardiography was performed after five minutes (timepoint #5).?After ten minutes, the MYK-461 infusion rate was lowered to 0.15 mg/kg/hr IV, a blood sample was drawn and an echocardiogram performed (timepoint #6).?Following imaging, the isoproterenol infusion was discontinued.?When heart rate returned to baseline levels (five to seven minutes), a complete echocardiogram was performed on MYK-461 alone (timepoint #7).?Study drug was then discontinued, and animals were awakened, extubated and moved to recovery.?Three of five cats were available to return for a control arm of this experiment after a 6-week washout period.The experiment was completed with identical methodology with the exception that MYK-461 was substituted for vehicle (control) at matched volumes/infusion rates[2].
体外活性	MYK-461的研究显示，在牛体系中具有490 nM的IC50值，在人体系中为711 nM，在兔体系中为2140 nM，表明其对心脏肌球蛋白的选择性大于四倍[1]。
体内活性	MYK-461 降低心脏收缩力，防止左心室肥大，并逆转病理性重塑。在猫中，它缓解左心室流出道阻塞[2]。
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
溶解度	10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (7.32 mM), Sonication is recommended. DMSO : 62.5 mg/mL (228.66 mM), Sonication is recommended.
关键字	SAR-439152 \| SAR 439152 \| Myosin \| MYK461 \| MYK 461 \| Mavacamten \| Inhibitor \| inhibit \| human cardiac \| bovine cardiac
相关产品	Myosin V-IN-1 \| Aficamten \| Blebbistatin \| JB002 \| ATM-3507 \| BTS \| 4-Hydroxyacetophenone \| JB061 \| Shz 1 \| BPN 0026709 \| (-)-Blebbistatin \| JB062
相关库	抑制剂库 \| 经典已知活性库 \| 已知活性化合物库 \| 肝脏毒性化合物库 \| EMA 上市药物库 \| FDA上市及药典收录分子库 \| 抗心血管疾病化合物库 \| 上市药物库 \| NO PAINS 化合物库 \| FDA 上市药物库 \| 临床期小分子药物库 \| 药物功能重定位化合物库

SAR439152|||MYK-461|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(13年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子