普乐沙福|T1776

Plerixafor
110078-46-1

￥163 1mg 起订

￥343 5mg 起订

￥572 10mg 起订

上海更新日期：2026-01-06

TargetMol中国（陶术生物）

VIP13年

联系人：邵小姐

电话：021-021-33632979拨打

手机：15002134094 拨打

邮箱：marketing@targetmol.com

产品详情:

中文名称：: 普乐沙福

英文名称：: Plerixafor

CAS号：: 110078-46-1

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

纯度规格：: 99.17%

产品类别：: 抑制剂

货号：: T1776

Product Introduction

Bioactivity

名称	Plerixafor
描述	Plerixafor (AMD-3329), a chemokine receptor antagonist, blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4.
细胞实验	Plerixafor is dissolved in DMSO and then diluted with appropriate medium[2]. U87 mg cells are seeded in 96-well plates at the density of 6×103 cells in 200 μL/well and treated with CXCL12, Plerixafor or with peptide R, as described in the previous "Treatments" section. MTT (5 μg/mL) is added at each time point (24, 48, 72 h) during the final 2 h of treatment. After removing cell medium, 100 μL DMSO are added and optical densities measured at 595 nm with a LT-4000MS Microplate Reader. Measurements are made in triplicates from three independent experiments[2].
激酶实验	In vitro biochemical assays against histone acetylases: GSK503 is profiled to assess inhibition against a panel of histone acetylases. GSK503 is dissolved in DMSO and tested in 10-dose IC50 mode with 3-fold serial dilution starting at 100 μM, with a final DMSO concentration of 2%. Anacardic Acid is used as positive control for CBP, GCN5, and pCAF and tested in 10-dose IC50 mode with 3-fold serial dilution starting at 100 μM. Curcumin is used as positive control for KAT5, MYST2/KAT7, MYST4/KAT6B, and p300, and tested in 10-dose IC50 mode with 3-fold serial dilution starting at 100 μM. Reactions are carried out at 3.08 μM Acetyl-CoA. For CBP, GCN5, MYST2/KAT7, pCAF, and p300, the substrate used is histone H3. For KAT5 and MYST4/KAT6B the substrates used are histone H2A and histone H4, respectively.
体外活性	Plerixafor以略优于其对CXCR4亲和力的效力，抑制了CXCL12介导的趋化作用。[1] Plerixafor还以IC50为651 nM对SDF-1/CXCL12配体结合产生拮抗作用。对于SDF-1介导的GTP结合、SDF-1介导的钙流和SDF-1刺激的趋化作用，Plerixafor的IC50分别为27 nM、572 nM和51 nM。Plerixafor不抑制表达CXCR3、CCR1、CCR2b、CCR4、CCR5或CCR7的细胞在其相应配体刺激下的钙流，也不抑制LTB4的受体结合。Plerixafor本身不在表达多种GPCRs（包括CXCR4、CCR4和CCR7）的CCRF-CEM细胞中诱导钙流。[2]
体内活性	单次局部施用Plerixafor能通过增加细胞因子产生、动员骨髓EPCs、增强成纤维细胞和单核细胞/巨噬细胞的活性，从而促进糖尿病小鼠的伤口愈合，同时增加血管生成和血管形成。[3] 小鼠连续五天被给予PBS、IGF1、PDGF、SCF或VEGF，并在第5天给予Plerixafor。与PDGF、SCF和VEGF处理组相比，IGF1加Plerixafor注射的小鼠群体中，克隆的数量和大小最大。[4]
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
溶解度	PBS : 1 mg/mL (1.99 mM), Solution. Ethanol : 242.5 mg/mL (482.32 mM), Sonication is recommended. DMSO : < 1 mg/mL (insoluble or slightly soluble), Sonication is recommended. H2O : Insoluble
关键字	VirusProtease \| Virus Protease \| stream \| stem \| SID-791 \| SID791 \| SID 791 \| Plerixafor \| peripheral \| myeloma \| multiple \| mobilizer \| lymphoma \| ligand \| JM-3100 \| JM 3100 \| Inhibitor \| inhibit \| Human immunodeficiency virus \| human \| HIVProtease \| HIV Protease \| HIV \| G-CSF \| CXCR4 \| CXCR \| CXCL12 \| CXC chemokine receptors \| cells \| cancer \| blood \| AMD3329 \| AMD-3100 \| AMD3100 \| AMD 3329
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普乐沙福|||JM3100|||AMD-3329|||AMD 3100|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(13年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子