酮咯酸氨丁三醇|T1212

Ketorolac tromethamine salt
74103-07-4

￥118 25mg 起订

￥158 50mg 起订

￥218 100mg 起订

上海更新日期：2024-12-02

TargetMol中国（陶术生物）

VIP12年

联系人：邵小姐

电话：021-021-33632979拨打

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产品详情:

中文名称：: 酮咯酸氨丁三醇

英文名称：: Ketorolac tromethamine salt

CAS号：: 74103-07-4

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 99.85%

产品类别：: 抑制剂

货号：: T1212

Product Introduction

Bioactivity

名称	Ketorolac tromethamine salt
描述	Ketorolac tromethamine salt (Ketorolac tris salt) non-selective inhibits the enzymes cyclooxygenase 1 (COX-1) and COX-2with anti-inflammatory, analgesic, and antipyretic activities.
细胞实验	Human osteoblasts cells are exposed to Ketorolac for 24 hours. Thymidine incorporation is assessed by the TopCount Microplate Scintillation and Luminescence Counters through adding [3H]-thymidine to cultures 4 hours prior to harvesting. Cell cycle distribution is determined by using propidium iodide in flow cytometer, and cell apoptosis or necrosis is detected using the Annexin V-FITC Apoptosis Detection Kit. (Only for Reference)
激酶实验	Inhibition of Prostaglandin Formation: Recombinant COX-1 and COX-2 from rat (rCOX) and human (hCOX) expressed in a baculovirus system are purified and reconstituted with 2 mM phenol and 1 μM hematin. Then the cyclooxygenase activity is measured using a radiometric assay, and the specific activity of the final enzyme preparations used is between 20,000 and 35,000 units. Ketorolac (2 -15 μL) are diluted in DMSO and preincubated with the appropriate recombinant COX (3 -15 ng) at a final concentration of 0.01 to 1000 μM in a reaction mixture (150 μL) containing 50 mM Tris-HCl buffer (pH 7.9), 2 mM EDTA, 10% glycerol, 2 mM phenol, and 1 μM hematin for 10 minutes. The reaction is initiated by addition of [14C]arachidonic acid (50–60 mCi/mmol in a final concentration of 20 μM) and is terminated 45 seconds later by the addition of 100 μL of 0.2 N HCl and 750 μL of distilled water. The total reaction volume is then applied to a 1 mL C18 Sep-pak column that has previously been washed with 2 mL of methanol followed by 5 mL of deionized water. Oxygenated products are eluted with 3 mL of a mixture of acetonitrile/water/acetic acid (50:50:0.1, v/v/v) and quantified by liquid scintillation spectroscopy.
体外活性	在乙酸诱导的扭体（ID50=0.24 mg/kg）,角叉菜胶诱导的爪痛觉过敏（ID50=0.29 mg/kg）和角叉菜胶诱导的大鼠水肿（ID50=0.08 mg/kg）形成试验中,（R,S）-Ketorolac能够发挥功效.
体内活性	在HEL细胞（COX-1）（IC50=0.025 μM）和LPS刺激的Mono Mac 6细胞（COX-2）（IC50=0.039 μM）中,Ketorolac抑制类花生酸形成。在人成骨细胞（hOB）中,] Ketorolac以剂量依赖性方式抑制胸苷掺入和细胞在G0 / G1期的增殖,阻滞细胞周期。
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 65 mg/mL (172.69 mM) H2O : 14 mg/mL (37.2 mM) Ethanol : 70 mg/mL (186 mM)
关键字	Cyclooxygenase \| RS37619 \| RS-37619 \| Ketorolac tromethamine \| Ketorolac tromethamine salt \| Inhibitor \| inhibit \| Ketorolac tris \| RS 37619 \| COX \| Ketorolac
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酮咯酸氨丁三醇|||Toradol|||Ketorolac tris salt|||Acular LS|||Acular|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(12年)
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