雌二醇|T1048

Estradiol
50-28-2

￥465 100mg 起订

￥232 25mg 起订

￥332 50mg 起订

上海更新日期：2024-12-02

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产品详情:

中文名称：: 雌二醇

英文名称：: Estradiol

CAS号：: 50-28-2

品牌：: TargetMol

产地：: 美国

保存条件：: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 99.58%

产品类别：: 抑制剂

货号：: T1048

Product Introduction

Bioactivity

名称	Estradiol
描述	Estradiol (E2) is a naturally occurring steroidal sex hormone that is essential for female fertility and maintenance of secondary sexual characteristics. Estradiol upregulates IL-6 expression through estrogen receptor beta (ERβ).
细胞实验	Estradiol is dissolved in 0.01% ethanol. Briefly, B9 cells (5×103/well of a 96-well plate) are cultured with a series of dilutions of the supernatants in a final volume of 100 mL of RPMI 1640, supplemented with 5×10-5mol/Lof 2-mercaptoethanol, 10% FBS, 100 U/mL penicillin, and 100 μg/mL streptomycin in flat-bottom microtiter plates. After 42 h, 0.5 μCi of [3H]thymidine is added. 6 h later, the cells are harvested and the radioactivity incorporated is determined. IL-6 is quantitated from a standard curve set up with known amounts of recombinant human or mouse IL-6. The anti-IL-6 monoclonal antibody completely inhibited the ability of the B9 cells to proliferate in response to recombinant mouse IL-6. In addition, we determined that B9 cells do not proliferate in response to IL-I or TNF, and that antibodies to these two cytokines did not affect the cell proliferation in response to IL-6. Further, it is established that neither Estradiol (17β-estradiol), nor the 0.01% ethanol used as vehicle in these experiments, has any effect on the bioassay.
体外活性	方法：人晶状体上皮细胞 HLEC 用 Estradiol (0.001-10 μM) 处理 24 h，使用 MTT 方法检测细胞活力。结果：在 10 μM Estradiol 的情况下，活细胞数量显著减少。[1] 方法：人乳腺癌细胞 MB231 用 Estradiol (100 nM) 处理 24 h，使用 scratch/wound healing assay 和 transwell assay 检测细胞运动情况。结果：Estradiol 治疗可减少 MB231 细胞的迁移和侵袭。[2]
体内活性	方法：为检测体内活性，将 Estradiol (0.2 mg/kg) 和 progesterone (5-20 mg/kg) 单次腹腔注射给切除卵巢的 C57BL/6 雌性小鼠。结果：单独接受 Estradiol 或 Estradiol 加 10-20 mg/kg progesterone 的小鼠对新物体的记忆显著增强。[3] 方法：为检测体内活性，将 Estradiol (0.2 mg/kg) 灌胃给药给卵巢切除的 C57BL/6 雌性小鼠，每天一次，持续两周。结果：长期激活 ERβ 可以减少去卵巢小鼠的热闪光样症状，增强空间和物体识别记忆。[4]
存储条件	keep away from direct sunlight \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	Ethanol : 20.4 mg/mL (75 mM) DMSO : 50 mg/mL (183.57 mM) 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2.72 mg/mL (9.99 mM), Suspension. Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.
关键字	Estrogen \| E-2 \| steroid sex hormone \| neural differentiation \| E 2 \| Inhibitor \| 17b-Estradiol \| Estrogen Receptor/ERR \| 17beta-Estradiol \| beta-Estradiol \| 17beta-Oestradiol \| human endometrial stem cells \| inhibit \| Endogenous Metabolite \| Estradiol \| 17b-Oestradiol \| uterine fibroids \| b-Estradiol
相关产品	Oleamide \| p-Hydroxybenzaldehyde \| Guanidine hydrochloride \| Naringin \| Daidzein \| Glycerol \| Sucrose \| Oxalic acid dihydrate \| Ferulic Acid \| 3-Indoleacetic acid \| Thymidine \| Fumaric acid
相关库	抗癌上市药物库 \| 经典已知活性库 \| 人内源代谢化合物库 \| EMA 上市药物库 \| 抗癌天然产物库 \| FDA 上市药物库 \| 天然产物库 \| 中药单体化合物库 \| 药物功能重定位化合物库 \| 抗癌临床化合物库

雌二醇|||β-Estradiol|||E2|||17β-Oestradiol|||17β-Estradiol|TargetMol

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成立日期	(12年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子