5-碘代杀结核菌素|T6745

5-Iodotubercidin
24386-93-4

￥315 1mg 起订

￥447 2mg 起订

￥715 5mg 起订

上海更新日期：2024-09-14

TargetMol中国（陶术生物）

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产品详情:

中文名称：: 5-碘代杀结核菌素

英文名称：: 5-Iodotubercidin

CAS号：: 24386-93-4

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 99.98%

产品类别：: 抑制剂

货号：: T6745

Product Introduction

Bioactivity

名称	5-Iodotubercidin
描述	5-Iodotubercidin (NSC-113939) is a potent adenosine kinase inhibitor with IC50 of 26 nM. It inhibits nucleoside transporter, CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC.
细胞实验	HeLa cells are grown in DME supplemented with 10% fetal bovine serum (FBS) and 2 mM?l-glutamine. Nocodazole is used at a concentration of 3.3 μM unless differently specified. Thymidine (2.5 mM) is used in the asssay. For transfection, FuGENE 6 Transfection Agent is used at a 3:1 ratio with plasmid DNA. Cells are analyzed 24-48 h after transfection.
激酶实验	AK activity is measured in a radiochemical assay. The final reaction volume is 100 μL and contained 70 mM Tris-maleate (pH 7.0), 0.1% (w/v) bovine serum albumin, 1.0 mM MgCl2, 1.0 mM ATP, 1.0 μM [U-14C]adenosine (400-600 mCi/mmol) and various inhibitor concentrations. Inhibitors are prepared as 10 mM stock solutions in DMSO. The final DMSO concentration in the assay is 5% (v/v). Eleven different concentration of the test solutions ranging from 0.001 to 10.0 μM are utilized to determine a dose response curve of the inhibition of the enzyme. Reactions are started by adding the appropriate amount of purified human recombinant AK and incubated for 20 min at 37°C. The reactions are terminated by addition of the potent AKI GP3269. A 30-μL aliquot of each reaction is spotted on DEAE cellulose filter paper (cut in squares of appr 1×1 cm) and air-dried for 30 min. The dry filters are then washed for 3 min in deionized water to remove residual [U-14C]adenosine, rinsed with ethanol and dried at 90°C for 20 min. The filter papers are counted in 5.5 mL of Ready Safe liquid scintillation cocktail using a Beckman LS3801 scintillation counter. Control AK activity is determined from the amount of [14C]AMP formed in the presence of 5% DMSO. The concentration of inhibitor required to inhibit 50% of the AK activity (IC50) is determined graphically from plots of inhibitor concentration versus percent (%) control enzyme activity.
动物实验	Animal Models: Male Mongolian gerbilsFormulation: salineDosages: 1, 2.5 and 5 mg/kgAdministration: i.p.
体外活性	5-Iodotubercidin（Itu）是一种具有抗肿瘤活性的基因毒性药物，能够激活Atm-p53途径。与其他核苷类似物相比，Itu独特之处在于它以p53依赖的方式诱导G2阶段阻滞。此外，在较高剂量下，Itu可能激活p53独立途径，这可能与p53合作，杀死细胞并抑制肿瘤生长。Itu代谢产物整合到DNA中会导致DNA断裂，从而触发DNA损伤响应。Itu可能是一种具有独特作用机制的潜在化疗化合物[2]。
体内活性	5-Iodotubercidin是一种在大鼠大脑中强效的腺苷激酶抑制剂。该化合物在小鼠中表现出显著的降血压、肌肉松弛及降低体温作用，这些效果可被茶碱（一种腺苷受体拮抗剂）阻断。尽管已知5-Iodotubercidin (1 mg/kg, i.p.)在缺血发作前使用可以增强脑片段中的细胞外腺苷水平，但其在通过运动或组织病理学指标评估时，未能提供任何脑保护作用。
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 19.6 mg/mL (50 mM)
关键字	5-Iodotubercidin \| Inhibitor \| 5Iodotubercidin \| NSC113939 \| inhibit \| 5 Iodotubercidin \| ADK \| NSC-113939 \| Adenosine Kinase
相关产品	Adenosine 5'-monophosphate monohydrate \| Inosine \| Istradefylline \| Adenosine antagonist-1 \| Theophylline \| Acefylline \| Theobromine \| Aminophylline \| Theophylline monohydrate \| Diphylline \| FK-453 \| Doxofylline
相关库	抑制剂库 \| 经典已知活性库 \| 激酶抑制剂库 \| 抗病毒库 \| GPCR靶点分子库 \| 神经退行性疾病化合物库 \| 膜蛋白靶向化合物库 \| 酪氨酸激酶分子库

NSC 113939|||5-碘代杀结核菌素|||5-ITu|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(12年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子