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  • 2-甲烯基丁内酯|T5320

2-甲烯基丁内酯|T5320

Tulipalin A
547-65-9
117 200mg 起订
上海 更新日期:2024-12-02

TargetMol中国(陶术生物)

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联系人:邵小姐
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产品详情:

中文名称:
2-甲烯基丁内酯
英文名称:
Tulipalin A
CAS号:
547-65-9
品牌:
TargetMol
产地:
美国
保存条件:
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
纯度规格:
97.78%
产品类别:
抑制剂
货号:
T5320

Product Introduction

Bioactivity

名称Tulipalin A
描述Tulipalin A (α-methylene-γ-butyrolactone) (2-Methylenebutyrolactone) which has some phytotoxicity is a natural compound extracted from Tulipa gesneriana.
细胞实验The influence of TUPA on cell viability was measured using the MTT assay. Cells were seeded in flat bottom 96-well plates at a density of 4 x 10^5 cells/ml. Afterward, Jurkat cells were exposed to TUPA in concentrations ranging from 10 to 82 μM. THP-1 cells (4 x 10^5 cells / ml) were exposed to concentrations ranging from 20 to 163 μM. After incubation for 72 h under humidified conditions (5 % CO2, 37 °C), 10 μl of MTT (5 mg/ml) per well were added and cells were further incubated for 3 h. Subsequently, 200 μl DMSO was added for cell lysis and formazan solubilization following incubation of the plates for 15 min while shaking. Afterward, absorbance was recorded at 550 nm and 620 nm using a microplate reader. In each plate, cells remained either untreated (negative control) or were exposed to Etoposide (2.5 μM) as a positive control. Using linear regression of the cell viability as a function of the compound concentrations, the concentrations leading to viability decreases of 10 % and 50 %, respectively, were calculated [2].
体外活性Tulipalin A 引起的植物毒性表现为长期的过敏性接触性皮炎,这一点在暴露于百合及其栽培品种的花卉工作者中有文献记载[1]。THP-1细胞对Tulipalin A的处理显示出强大的鲁棒性,因为只有五种蛋白质发生了变化。相比之下,Jurkat T 细胞内66种蛋白质的数量增加,而6种蛋白质的数量减少[2]。
存储条件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 45 mg/mL (458.71 mM)
关键字inhibit | Drug Metabolite | Allergic contact dermatitides,dermatitis | Tulipalin A | phytotoxicity TUPA | a-methylene-r-butyrolactone | Inhibitor | α-Methylene butyrolactone | alpha-methylene-gamma-butyrolactone
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相关库经典已知活性库 | 植物来源化合物库 | 已知活性化合物库 | 藏药化合物库 | 药食同源库 | 天然产物库 | 中国药典收录天然产物库 | 萜类天然产物库 | 中药抗炎分子库 | 高通量筛选天然产物库
α-methylene-γ-butyrolactone|||2-甲烯基丁内酯|||2-Methylenebutyrolactone|TargetMol

公司简介

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起,为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部,化学事业部,生物事业部和新材料部。 从虚拟筛选到实体化合物分子供应;从商业化产品销售到个性化定制合成;从对明确靶点的分子筛选到对明确分子的多靶点筛选,从高通量筛选到化学结构优化,我们都可以满足您的科研用品及技术服务的需求。 经过在中国市场五年的精心耕耘,我们已成为筛选化合物领域优秀的供应商,为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期 (12年)
注册资本 566.2651万人民币
员工人数 100-500人
年营业额 ¥ 1亿以上
经营模式 贸易,试剂,定制,服务
主营行业 化学试剂,生物活性小分子

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