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Haloperidol (氟哌啶醇)

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基本信息:

  • 发布时间: 2017-06-12
  • 产品名称: Haloperidol (氟哌啶醇)
  • 产品英文名称: Haloperidol (氟哌啶醇)
  • CAS号: 52-86-8
  • 产品包装: 100mg
  • 产品价格: 450元/罐
  • 有效期: 一年

产品图片:

Haloperidol (氟哌啶醇)

产品描述:

Haloperidol的生物活性

 

Haloperidol blocks dopamine receptors in in the treatment of schizophrenia, acute psychosis, and delirium.
Target: Dopamine Receptors
Haloperidol is an antipsychotic medication used in the treatment of schizophrenia, acute psychosis, and delirium. Haloperidol is a butyrophenone derivative and functions as an inverse agonist of dopamine. It is classified as a typical antipsychotic and has pharmacological effects similar to the phenothiazines. A long-acting decanoate ester of haloperidol is used as an injection given every four weeks to people with schizophrenia or related illnesses who have poor adherence to medication regimens and suffer frequent relapses of illness, or to overcome the drawbacks inherent to its orally administered counterpart that burst dosage increases risk or intensity of side effects.
A review of haloperidol found that while it may be marginally effective in treatment of symptoms associated with schizophrenia, there is a high rate of adverse events. This conclusion may be overly generous as half of people did not complete the studies and some negative trials may have remained unpublished. It should only be used if other treatments are not a possibility. Treatment is merely symptomatic and involves intensive care with stabilization of vital functions. In early detected cases of oral overdose, induction of emesis, gastric lavage, and the use of activated charcoal can all be tried. Epinephrine is avoided for treatment of hypotension and shock, because its action might be reversed. In the case of a severe overdose, antidotes such as bromocryptine or ropinirole may be used to treat the extrapyramidal effects caused by haloperidol, acting as dopamine receptor agonists
 

 

化学信息

分子量
375.86
储存条件
参考CoA中推荐的条件进行储存。
分子式
C21H23ClFNO2
CAS号
52-86-8
溶剂/溶解度
DMSO 75 mg/mL (199 mM); Water <1 mg/mL (<1 mM)

 

相关文献

 

[1]. Joy CB, et al. Haloperidol versus placebo for schizophrenia. Cochrane Database Syst Rev. 2006 Oct 18;(4):CD003082.

[2]. Giannini AJ, et al. Acute ketamine intoxication treated by haloperidol: a preliminary study. Am J Ther. 2000 Nov;7(6):389-91.

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