aladdin 阿拉丁 R276229 Ro 48-8071,2,3-氧化鲨烯环化酶（OSC）抑制剂 189197-69-1 ≥98%

中文名：Ro 48-8071,2,3-氧化鲨烯环化酶（OSC）抑制剂

英文名：Ro 48-8071

中文别名：(4-溴苯基)-[2-氟-4-[6-[甲基(丙-2-烯基)氨基]己氧基]苯基]甲酮

英文别名：Ro 48-8071 fumarate|189197-69-1|Ro 48-8071 (fumarate)|Ro-48-8071 fumarate|Ro48-8071fumarate|(4-((6-(Allyl(methyl)amino)hexyl)oxy)-2-fluorophenyl)(4-bromophenyl)methanone fumarate|7YBF6VZ4ML|CHEMBL324162|(4-bromophenyl)-[2-fluoro-4-[6-[methyl(prop-2-enyl)a

纯度：≥98%

货号：R276229

包装：10mg、50mg、100mg

Cas号：189197-69-1

存储温度：避光,-20°C储存

产品介绍：

储存在室温下。该产品最多可存储12个月。

 An   benzofuranylallylamine compound that acts as a potent, active site targeting, competitive and reversible inhibitor of 2,3-oxidosqualene:lanosterol cyclase activity (OSC; IC50 ~ 6.5 nM against mammalian) and reduces cholesterol synthesis (IC50 ~ 1.5 nM in HepG2 cells) with minimal buildup of both dioxidosqualene and monooxidosqualene. Downregulates 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase mRNA and synthesis, and exerts less adverse effects in animal models than Statins. Shown to preferentially enhance the DNA-binding affinity of mutant p53 and arrest the growth of human breast cancer cells (IC50 ~ 10 µM).

An   benzofuranylallylamine compound that acts as a potent, active site targeting, competitive and reversible inhibitor of 2,3-oxidosqualene:lanosterol cyclase activity (OSC; IC50 ~6.5 nM against mammalian) and reduces cholesterol synthesis (IC50 ~1.5 nM in HepG2 cells) with minimal buildup of both dioxidosqualene and monooxidosqualene. Downregulates 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase mRNA and synthesis, and exerts less adverse effects in animal models than Statins. Shown to preferentially enhance the DNA-binding affinity of mutant p53 and arrest the growth of human breast cancer cells (IC50 ~10 µM).

Ro 48-8071 fumarate 是氧化鲨烯环化酶 (Oxidosqualene cyclase) 抑制剂，IC50 约为 6.5 nM。

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