189197-69-1
基本信息
(4-((6-(烯丙基(甲基)氨基)己基)氧基)-2-氟苯基)(4-溴苯基)甲酮富马酸盐
(4-溴苯基)[2-氟-4-[[6-(甲基-2-丙烯基氨基)己基]氧基]苯基]甲酮富马酸盐
Aids163155
Aids-163155
Ro 48-8071 fumarate salt
OSC Inhibitor, Ro 48-8071
RO 488071
RO48-8071
RO-48-8071
OSC Inhibitor, Ro 48-8071 - CAS 189197-69-1 - Calbiochem
(4-Bromophenyl)[2-fluoro-4-[[6-(methyl-2-propen-1-ylamino)hexyl]oxy]phenyl]methanone
Methanone, (4-bromophenyl)[2-fluoro-4-[[6-(methyl-2-propenylamino)hexyl]oxy]phenyl]-,(2E)-2-butenedioate
(4-Bromophenyl)[2-fluoro-4-[[6-(methyl-2-propen-1-ylamino)hexyl]oxy]phenyl]methanone (2E)-2-butenedioate (1:1)
物理化学性质
| 熔点 | 90-92.7 °C |
| 熔点 | 90-92.7 °C |
| 储存条件 | Inert atmosphere,Store in freezer, under -20°C |
| 溶解度 | H2O: >5 mg/mL at ~60 °C |
| 溶解度 | H2O:>5 mg/mLat ~60 °C |
| 形态 | solid |
| 颜色 | white |
常见问题列表
IC50: appr 6.5 nM (Oxidosqualene cyclase)
In HepG2 cells, Ro 48-8071 reduces cholesterol synthesis dose dependently with an IC 50 value of appr 1.5 nM. Ro 48-8071 (10 μM) significantly reduces the viability of PC-3 prostate cancer cells, but not normal prostate cells. Ro 48-8071 (10-30 μM) induces apoptosis of both LNCaP and C4-2 cell lines in a dose-dependent manner. And castration-resistant PC-3 and DU145 cells also demonstrate significant levels of apoptosis following 24-hour treatment with Ro 48-8071. Ro 48-8071 (10-25 μM) reduces AR protein expression in a dose-dependent manner. Ro 48-8071 (0.1-1 μM) increases ERβ protein expression dose-dependently in both hormone-dependent LNCaP and castration-resistant PC-3 cells. Using mammalian cells engineered to express human ERα or ERβ protein, together with an ER-responsive luciferase promoter, Ro 48-8071 dose-dependently inhibits 17β-estradiol (E2)-induced ERα responsive luciferase activity (IC 50 , appr 10 µM), under conditions that are non-toxic to the cells.
Ro 48-8071 lowers LDL-C maximally appr 60% at 150 μmol/kg per day, with no further reduction up to 300 μmol/kg per day, leaving HDL-C unchanged at all doses in hamsters. Ro 48-8071 (≥00 μmol/kg per day) increases the amount of MOS in liver of hamsters. Ro 48-8071 (300 μmol/kg per day) remarkedly and significantly reduces VLDL secretion of hamsters. Ro 48-8071 (5 or 20 mg/kg) significantly reduces in vivo tumor growth in mice, without weight loss of the mice. Furthermore, Ro 48-8071 at a concentration of 20 mg/kg, completely eradicates two of the 12 tumors being monitored in the mice in the timeframe tested. Ro 48-8071 (20 mg/day/kg body weight) leads to a rapid and sustained inhibition (>50%) of cholesterol synthesis in the whole small intestine of BALB/c mice. Sterol synthesis is also reduced in the large intestine and stomach.