aladdin 阿拉丁 W424498 蟛蜞菊内酯 524-12-9 10mM in DMSO

中文名：蟛蜞菊内酯

英文名：Wedelolactone

中文别名：7-甲氧基-5,11,12- 三羟基香豆素

英文别名：Wedelolactone|524-12-9|7-Methoxy-5,11,12-trihydroxycoumestan|7-Methoxy-5,11,12-trihydroxy-coumestan|IKK Inhibitor II|1,8,9-Trihydroxy-3-methoxycoumestan|CHEMBL97453|0K6L725GNS|CHEBI:10037|1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one|5,11,12

纯度：10mM in DMSO

货号：W424498

包装：1ml

Cas号：524-12-9

存储温度：-80℃储存

产品介绍：

Wedelolactone, a compound originally extracted from Eclipta alba, has been shown to inhibit caspase-11, which is a key regulator of proinflammatory cytokine IL-1β maturation and pathological apoptosis. Mechanistic studies suggest that caspase-11 is inhibited by reduction of NF-κB-mediated transcription. Furthermore, this compound has been shown to inhibit IKKγ, a kinase that is crucial for activation of NF-κB, as well as IKK α and IKK β. Weldelolactone also displays potent trypsin inhibition capacities. Additional studies suggest that Wedelolactone contains antagonistic properties towards two PLA2 myotoxins that were isolated from Agkistrodon contortix laticinctus and Crotalus virdis virdis. This agent has also been noted to contain antihepatotoxic behavior consequentially protecting primary cultured liver cells from the toxicity of CC14, Phalloidin, and galactosamine, and inhibit 5-lipoxygenase (5-LO)) activity in porcine leukocytes.

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