aladdin 阿拉丁 W124219 蟛蜞菊内酯 524-12-9 ≥98%(HPLC)

中文名：蟛蜞菊内酯

英文名：Wedelolactone

应用：Inhibits caspase-11; a key regulator of proinflammatory cytokine IL-1β maturation and apoptosis.

纯度：Moligand™，≥98%(HPLC)

货号：W124219

Cas号：524-12-9

存储温度：2-8°C储存

运输条件：低温运输

产品介绍：

Wedelolactone, a compound originally extracted from Eclipta alba, has been shown to inhibit caspase-11, which is a key regulator of proinflammatory cytokine IL-1β maturation and pathological apoptosis. Mechanistic studies sμggest that caspase-11 is inhibited by reduction of NF-κB-mediated transcription. Furthermore, this compound has been shown to inhibit IKKγ, a kinase that is crucial for activation of NF-κB, as well as IKK α and IKK β. Weldelolactone also displays potent trypsin inhibition capacities. Additional studies sμggest that Wedelolactone contains antagonistic properties towards two PLA2 myotoxins that were isolated from Agkistrodon contortix laticinctus and Crotalus virdis virdis. This agent has also been noted to contain antihepatotoxic behavior consequentially protecting primary cultured liver cells from the toxicity of CC14, Phalloidin, and galactosamine, and inhibit 5-lipoxygenase (5-LO)) activity in porcine leukocytes.Inhibits caspase-11; a key regulator of proinflammatory cytokine IL-1β maturation and apoptosis.

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