aladdin 阿拉丁 M409157 Medetomidine HCl 86347-15-1 10mM in DMSO

中文名：Medetomidine HCl

英文名：Medetomidine HCl

英文别名：1H-Imidazole, 5-[1-(2,3-dimethylphenyl)ethyl]-, hydrochloride (1:1)

纯度：10mM in DMSO

货号：M409157

包装：1ml

Cas号：86347-15-1

存储温度：-80℃储存

产品介绍：

Information

Medetomidine is a selectiveα2-adrenoceptoragonist, withKiof 1.08 nM, exhibts 1620-fold selectivity over α1-adrenoceptor.
In vitro

Medetomidine is a selectiveα2-adrenoceptor agonist, with K_i of 1.08 nM, exhibits 1620-fold selectivity over α1-adrenoceptor, has very weak or no binding to other neurotransmitter receptors.

In vivo

In anesthetized rats, medetomidine (1-100 μg/kg, i.v.) induces a dose-dependent, relatively short-lived reduction in blood pressure and heart rate. In the pithed rat, medetomidine shows very potent vasopressor (PD50 1.7 μg/kg) and sympatho-inhibitory (ID50 1.6 μg/kg) effects without affecting basal heart rate. Medetomidine induces dose-dependent sedation, which at high doses (>100μg/kg) includes loss of the righting reflex and hypothermia. Medetomidine induces a decreases in the turnover rate of biogenic amines in the brain, dose-dependently inhibits norepinephrine (NE) turnover, inhibits brain dopamine turnover at high doses, decreases serotonin turnover.
Cell Data

cell lines：Human microvascular endothelial cell line HMEC-1

Concentrations：

Incubation Time：

Powder Purity:≥99%

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