aladdin 阿拉丁 L408943 Linezolid (PNU-100766) 165800-03-3 10mM in DMSO

中文名：Linezolid (PNU-100766)

英文名：Linezolid (PNU-100766)

英文别名：(S)-N-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide

纯度：10mM in DMSO

货号：L408943

包装：1ml

Cas号：165800-03-3

存储温度：-80℃储存

产品介绍：

Information

Linezolid (PNU-100766) is a synthetic antibiotic used for the treatment of serious infections.
In vitro

Linezolid inhibits initiation complex formation with either the 30S or the 70S ribosomal subunits from Escherichia coli. Linezolid inhibits complex formation with Staphylococcus aureus 70S tight-couple ribosomes. Linezolid is a potent inhibitor of cell-free transcription-translation in E. coli, exhibiting 50% inhibitory concentrations (IC50s) of 1.8 mM. Linezolid\xa0is an oxazolidinone, a new class of antibacterial agents with enhanced activity\xa0against\xa0pathogens. Linezolid MICs vary slightly with the test method, laboratory, and significance attributed to thin hazes of bacterial survival, but all workers find that the susceptibility distributions are narrow and unimodal, with MIC values between 0.5 and 4 mg/L for streptococci, enterococci and staphylococci. Linezolid entails mutation of the 23S rRNA that forms the binding site. Linezolid is an oxazolidinone whose mechanism of action involves inhibition of protein synthesis at a very early stage. Linezolid is added to 7H10 agar medium (Difco) supplemented with OADC (oleic acid, albumin, dextrose, and catalase) at 50°C to 56°C by doubling the dilutions to yield a final concentration of 0.125 μg/mL to 4 μg/mL. Linezolid shows excellent in vitro activity against all the strains tested (MICs ≤ 1 μg/ml), including those resistant to SIRE.

In vivo

Cell Data

cell lines：U87, LN229, NIH3T3, HUVECs, BaF3 and TT thyroid carcinoma cells

Concentrations：

Incubation Time：

Powder Purity:≥99%

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