aladdin 阿拉丁 S288019 SU 16f,PDGFRβ抑制剂 251356-45-3 ≥98%(HPLC)

中文名：SU 16f,PDGFRβ抑制剂

英文名：SU 16f

中文别名：5-[1,2-二氢-2-氧代-6-苯基-3H-吲哚-3-亚甲基)甲基] -2,4-二甲基-1H-吡咯-3-丙酸

纯度：≥98%(HPLC)

货号：S288019

包装：10mg、50mg、100mg

Cas号：251356-45-3

存储温度：避光,-20°C储存

产品介绍：

产品介绍：
A cell-permeable indolinone compound that acts as a potent, ATP site-targeting PDGFR inhibitor (IC50 = 10 nM against PDGFRβ), while affecting Flk-1/KDR/ VEGFR2, FGFR1, and EGFR only at much higher concentrations (IC50 = 0.14, 2.29, and >100 µM, respectively). Reported to selectively inhibit PDGFβ- over EGF-stimulated proliferation in EGFR-expressing NIH 3T3 cultures (IC50 = 0.11 and 21.9 µM, respectively) and exhibit much weaker potency against the proliferation of HUVEC cells upon FGF or VEGF stimulation (IC50 = 10 µM).

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