化合物 T16947
化合物 T16947 性质
| 沸点 | 661.7±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.292±0.06 g/cm3(Predicted) |
| 储存条件 | Store at RT |
| 溶解度 | 在 DMSO 中溶解度为 100 mM |
| 形态 | 暗橙色固体 |
| 酸度系数(pKa) | 4+-.0.10(Predicted) |
| 颜色 | 黄至橙色 |
| InChI | 1S/C24H22N2O3/c1-14-18(10-11-23(27)28)15(2)25-21(14)13-20-19-9-8-17(12-22(19)26-24(20)29)16-6-4-3-5-7-16/h3-9,12-13,25H,10-11H2,1-2H3,(H,26,29)(H,27,28)/b20-13- |
| InChIKey | APYYTEJNOZQZNA-MOSHPQCFSA-N |
化合物 T16947 用途与合成方法
|
PDGFRβ 10 nM (IC 50 ) |
PDGFR2 140 nM (IC 50 ) |
PDGFR1 2.29 μM (IC 50 ) |
SU16f (20 μM; for 8 hours) pretreatment inhibits the promoting role of GC-MSC-CM in SGC-7901 cell proliferation.
SU16f (20 μM; for 8 hours) significantly abolishes PDGFRβ activation in SGC-7901 by GC-MSC-CM. SU16f pretreatment results in the upregulation of E-cadherin and downregulation of N-cadherin, Vimentin, and α-SMA. SU16f pretreatment leads to downregulation of p-AKT, Bcl-xl, and Bcl-2 levels and upregulation of Bax expression in SGC-7901 cells by GC-MSC-CM .
Cell Proliferation Assay
| Cell Line: | SGC-7901 cells in GC-MSC/SGC-7901 co-culture system |
| Concentration: | 20 μM |
| Incubation Time: | 8 hours |
| Result: | Inhibited the promoting role of GC-MSC-CM in SGC-7901 cell proliferation. |
Western Blot Analysis
| Cell Line: | SGC-7901 cells |
| Concentration: | 20 μM |
| Incubation Time: | 8 hours |
| Result: | Significantly abolished PDGFRβ activation in SGC-7901 by GC-MSC-CM, and resulted in the upregulation of E-cadherin and downregulation of N-cadherin, Vimentin, and α-SMA. |
化合物 T16947 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025-12-22 | HY-108628 | 化合物 T16947 | 251356-45-3 | 1 mg | 480 |
| 2025-12-22 | HY-108628 | 化合物 T16947 | 251356-45-3 | 10 mM * 1 mLin DMSO | 833 |
