VE-822

广东更新日期：2019-10-28

珠海市活力达生物科技有限公司

非会员

联系人：彭小姐

电话：15572952737拨打

邮箱：2414839437@qq.com

产品详情:

中文名称：: VE-822

CAS号：: 1232416-25-9

lt;span style="font-family: Arial, Helvetica, sans-serif;line-height: 19.1875px;">VE-822 is an potent ATR inhibitor.VE-822 inhibited ATR in vitro and in vivo. VE-822 decreased maintenanceof cell-cycle checkpoints, increased persistent DNA damage and decreasedhomologous recombination in irradiated cancer cells. VE-822 decreasedsurvival of pancreatic cancer cells but not normal cells in response toXRT or gemcitabine. VE-822 markedly prolonged growth delay of pancreaticcancer xenografts after XRT and gemcitabine-based chemoradiation withoutaugmenting normal cell or tissue toxicity. These findings support ATRinhibition as a promising new approach to improve the therapeutic rationof radiochemotherapy for patients with PDAC.</span>