aladdin 阿拉丁 O413886 奥扎莫德（RPC1063） 1306760-87-1 98%

中文名：奥扎莫德（RPC1063）

英文名：Ozanimod (RPC1063)

纯度：Moligand™，≥98%

货号：O413886

Cas号：1306760-87-1

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

Ozanimod (RPC1063) Ozanimod (RPC1063) is a selective oral S1P Receptor 1 modulator. Phase 3.

Targets

S1P1R (Cell-free assay); S1P5R (Cell-free assay) 0.41 nM(EC50); 11 nM(EC50)

In vitro

In S1P1R-HEK293T cells, Ozanimod induces sustained S1P1R internalization and degradation.

In vivo

Ozanimod shows high oral bioavailability and volume of distribution. In a MOG-induced EAE mouse model, Ozanimod (3 mg/kg, p.o.) suppresses clinical symptoms. In a rat TNBS model of inflammatory bowel disease, Ozanimod (1.2 mg/kg, p.o.) inhibits clinical and histological disease scores. In a Naïve CD4+CD45Rbhi T cell adoptive transfer model, Ozanimod (1.2 mg/kg, p.o.) also significantly reduced disease severity as assessed by measuring the degree of inflammation, gland loss, hyperplasia, neutrophil infiltrate and mucosal thickness.

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