aladdin 阿拉丁 M413917 Molidustat (BAY 85-3934) 1154028-82-6 98%

中文名：Molidustat (BAY 85-3934)

英文名：Molidustat (BAY 85-3934)

纯度：Moligand™，≥98%

货号：M413917

Cas号：1154028-82-6

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

Molidustat (BAY 85-3934) Molidustat (BAY 85-3934) is a potent hypoxia-inducible factor prolyl hydroxylase ( HIF-PH ) inhibitor with IC50 of 480 nM, 280 nM, and 450 nM for PHD1, PHD2, and PHD, respectively. Phase 2.

Targets

PHD2 (Cell-free assay); PHD3 (Cell-free assay); PHD1 (Cell-free assay) 280 nM; 450 nM; 480 nM

In vitro

Molidustat induces the transcription of hypoxia-sensitive genes in HeLa, A549, and Hep3B cells.

In vivo

In healthy Wistar rats and cynomolgus monkeys, Molidustat (1.5 mg/kg, p.o.) induces dose-dependent production of EPO and erythropoiesis. In rats with gentamicin-induced renal anemiabe, Molidustat (5 mg/kg, p.o.) is also effective in raising hematocrit levels while stimulating endogenous EPO production without hypertensive effects.

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